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. 2019 Oct;8(6):2252–2263. doi: 10.21037/tcr.2019.09.38

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2019 Translational Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

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Kif18a regulates the expression of EMT-related proteins through Akt. (A,B) Down-regulated expression of KIF18A in 6-10B inhibited the protein expression of Vimentin, Akt and p-Akt, promoted the expression of E-cadherin; (C,D) up-regulated expression of KIF18A in Tu686 promoted the protein expression of Vimentin, Akt and p-Akt, inhibited the expression of E-cadherin; (E,F) in KIF18A up-regulated Tu686 cells, Akt inhibitor can reversed the protein expression of vimentin and E-cadherin. *, P<0.05.