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. 2019 Feb;8(1):35–43. doi: 10.21037/tcr.2018.12.26

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2019 Translational Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

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BLACAT1 is highly expressed in CRC tissues and cell lines. BLACAT1 expression, as measured using Affymetrix microarray, was higher in CRC tissues than in normal colon mucosal tissues in (A) GSE22598 (consisting of 17 pairs of CRC tissues and corresponding normal colorectal tissues) samples from the GEO database, (B) GSE23878 (consisting of 24 normal colorectal tissues and 35 CRC tissue biopsies), and (C) GSE9348 (consisting of 12 normal colorectal tissues and 70 CRC tissue biopsies). (D) BLACAT1 expression increased significantly in CRC cell lines (SW480, SW620, HCT116, and CaCO₂) compared to in NCM460, a normal colon mucosal cell line. Data show mean ± SEM. *, P<0.05; **, P<0.01; ***, P<0.001 compared to control. CRC, colorectal cancer.