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. 2019 Apr;8(2):664–675. doi: 10.21037/tcr.2019.04.04

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2019 Translational Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

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RRAS is down-regulated in NPC and correlates with poor prognosis. (A) Expression level of RRAS mRNA in nasopharyngeal cell lines and immortalized epithelial cell line NP69; (B) the expression level of RRAS mRNA in 16 NPC tissues and 15 noncancerous nasopharyngeal tissues; (C) the expression level of RRAS protein in NPC cell lines and the immortalized epithelial cell line NP69 was analyzed by western blot; (D) representative immunohistochemical staining of RRAS protein in NPC specimens; (E) Kaplan-Meier survival analysis indicated that patients with high expression of RRAS had a longer overall survival (OS), but had no significant correlation with progression-free survival (PFS). P<0.05 was regarded as statistically significant. **, P<0.01; ***, P<0.001. NPC, nasopharyngeal carcinoma.