Table 1. The Potential algorithm of therapy for extended locally advanced esophageal cancer and salvage treatment.

	Early esophageal cancer	Extended esophageal cancer	Locally advanced esophageal cancer	Salvage treatment for local failure of esophageal cancer
Algorithm of therapy	esophagectomy (10)	nimotuzumab combined with chemotherapy (30)	DCF therapy with prophylactic administration of pegfilgrastim (31)	Salvage surgery (32)
	ESD (miR-205 levels may serve as a marker) (33,34)	HiPorfin Photodynamic Therapy (35)	targeted therapy: Gefitinib (36): lapatinib combined with paclitaxel (37)	ER (38)
	EMR (remove lesions only smaller than 2 cm en bloc) (39,40)	combined immunotherapy and chemotherapy (41)	CRT (37)	repeated tPDT (42)

DCF, Docetaxel, cisplatin, and 5-FU; ER, endoscopic resection; CRT, Chemoradiotherapy; tPDT, talaporfin sodium photodynamic therapy; ESD, endoscopic submucosal dissection; EMR, endoscopic mucosal resection.