Table 5. List of common circRNA biomarkers for esophageal cancer.
| Name | Expression | Mechanism | Biomarker potency | Study setting | Detection method | Reference |
|---|---|---|---|---|---|---|
| ciRS-7 | ↑ (175) | As miR-876-5p and miR-7sponge, inhibit them to regulate antigen MAGE-A family in ESCC (175,176) | (i), (iii) (175) | Tumor (a) | RT-PCR | (175,176) |
| CircHIPK3 | ↑ | Regulate P53-Akt-Mdm2 signal pathway in ESCC | (iii) | Tumor (a) | RT-qPCR, Bioinformatics analysis, WB | (177,178) |
| circ-0006168 | ↑ | Target regulate miR-100/mTOR and miR-339-5p/CDC25A pathway | (i), (iii) | Tumor, cell (a) | RT-qPCR, Dual-Luciferase reporter system | (179) |
| hsa_circ0004771 | ↑ | Regulate miR-339-5p/CDC25A pathway in ESCC | (i), (ii) (low invasive biomarker) | plasma (a) | RT-qPCR | (180) |
| circVRK1 | ↓ | Regulate miR-624-3p/PTEN/PI3K/AKT signaling pathway | (iii) | Tumor, cell (a) | RT-qPCR | (181) |
| circ-ITCH | ↓ | Make miR-7, miR-17, miR-214 molecular sponges, enhancing the expression of ITCH to ubiquitin degrade phosphorylated DVL2 and thus inhibit the development of the Wnt pathway in ESCC | (iv) | Tumor, cell, mice (a, b) | RT-qPCR, Bioinformatics analysis, WB, Tumor formation study | (182,183) |
| circ-0043898 | ↓ | Participate in the synthesis of tumor proteoglycan and RAP1 and mTOR signaling pathways | (i), (iii) | Tumor, cell, mice (a, b) | RNA-seq, RT-PCR, GO, KEGG, Tumor formation study | (164,184) |
↑, represents up-regulated gene expression in tumor tissue, ↓, represents down-regulated gene expression in tumor tissue, (i) diagnostic, (ii) prognostic and (iii) therapeutic (iv) metastasis monitoring, a in-vitro, b, in-vivo, c, in-situ, RT-qPCR, real-time quantitative PCR, WB, western blot, RT-PCR, reverse transcription PCR, ESCC, esophageal squamous cell cancer.