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. 2019 Feb;8(1):290–297. doi: 10.21037/tcr.2019.01.37

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2019 Translational Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

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Evaluation of response to radiotherapy by targeting HK2 gene in TNBC xenografts. (A) The growth rates of Lv-shHK2 group with or without IR were significantly slower than Lv-shNC after a serial observation of 28 days (*, P<0.05 vs. shNC; ^##, P<0.01 vs. shNC + IR); (B) ¹⁸F-FDG micro PET/CT images of mice treated with radiotherapy at day 0, 1 and 7. Quantification of tumor uptake of ¹⁸F-FDG is presented as SUVmax (**, P<0.01 vs. shNC). IR, irradiation; TNBC, triple-negative breast cancer; HK2, hexokinase 2; PET, positron emission tomography; CT, computed tomography.