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. 2021 Jun;10(6):3128–3139. doi: 10.21037/tcr-20-2815

Table 1. Main studies focused on exosomal miRNAs used as diagnostic biomarkers in NSCLC.

Exosomal miRNAs Source Clinical value Reference
miR-378a, miR-379, miR-139-5p, and miR-200b-5p Plasma Diagnostic biomarkers to differentiate adenocarcinoma and healthy subjects (39)
miR-19-3p, miR-21-5p and miR-221-3p Plasma Diagnostic biomarkers for lung adenocarcinoma (40)
miR-331-5p, miR-451a, miR-363-3p Plasma Diagnostic biomarkers for distinguishing SCLC from NSCLC (41)
miR-451a, miR-486-5p, miR-363-3p, miR-660-5p, miR-15b-5p, miR-25-3p and miR-16-2-3p Plasma Diagnostic biomarkers to differentiate adenocarcinoma from healthy subjects (41)
miR-126 Plasma Diagnostic biomarker for NSCLC (42)
miR-21, miR-205 and miR-155 Plasma Diagnostic biomarkers for early-stage NSCLC (43)
miR-let-7b-5p, miR-let-7e-5p, miR-23a-3p and miR-486-5p Plasma Diagnostic biomarkers of stage I NSCLC patients (44)
miR-181-5p, miR-30a3p, miR-30e-3p and miR-361-5p Plasma Diagnostic biomarkers for lung adenocarcinoma (44)
miR-10b-5p, miR-15b-5p and miR-320b Plasma Diagnostic biomarkers for SCC (44)
miR-205, miR-19a, miR-19b, miR-30b and miR-20a Plasma Diagnostic biomarkers for SCC after surgery (45)
miR-205-5p, miR-483-5p, miR-375, miR-200c-3p, miR-429, miR-200b-3p, miR-200a-3p, miR-203a-3p and miR-141-3p Pleural fluid Diagnostic biomarkers for discriminating lung adenocarcinoma over tuberculosis and other benign lesions (47,48)
miR-200 Pleural fluid Diagnostic biomarker for discriminating lung adenocarcinoma from benign effusions (49)
miR-182 and miR-210 Pleural fluid Diagnostic biomarkers for distinguishing lung adenocarcinoma from benign effusions (50)