Table 2. Correlations from TCGA and data analysis.
| Characteristics | ADRB1 | ADRB2 | ADRA2A | ADRA1A | CHRNA2 | CHRM3 | CHRM1 | CHRNA5 |
|---|---|---|---|---|---|---|---|---|
| Correlations from TCGA | ||||||||
| ADRB1 | ||||||||
| Pearson correlation | 1 | 0.304** | –0.159** | –0.107* | 0.134** | –0.016 | –0.018 | 0.037 |
| Sig. (two-tailed) | 0.000 | 0.000 | 0.024 | 0.003 | 0.732 | 0.697 | 0.418 | |
| N | 494 | 494 | 493 | 450 | 493 | 465 | 494 | 494 |
| ADRB2 | ||||||||
| Pearson correlation | 0.304** | 1 | –0.166** | –0.130** | –0.077 | 0.026 | –0.119** | –0.145** |
| Sig. (two-tailed) | 0.000 | 0.000 | 0.006 | 0.087 | 0.569 | 0.008 | 0.001 | |
| N | 494 | 494 | 493 | 450 | 493 | 465 | 494 | 494 |
| ADRA2A | ||||||||
| Pearson correlation | –0.159** | –0.166** | 1 | 0.030 | –0.063 | –0.008 | 0.087 | –0.165** |
| Sig. (two-tailed) | 0.000 | 0.000 | 0.532 | 0.163 | 0.867 | 0.053 | 0.000 | |
| N | 493 | 493 | 493 | 450 | 492 | 465 | 493 | 493 |
| ADRA1A | ||||||||
| Pearson correlation | –0.107* | –0.130** | 0.030 | 1 | –0.010 | –0.062 | 0.096* | –0.073 |
| Sig. (two-tailed) | 0.024 | 0.006 | 0.532 | 0.841 | 0.196 | 0.042 | 0.124 | |
| N | 450 | 450 | 450 | 450 | 449 | 434 | 450 | 450 |
| CHRNA2 | ||||||||
| Pearson correlation | 0.134** | –0.077 | –0.063 | –0.010 | 1 | –0.126** | 0.499** | 0.256** |
| Sig. (two-tailed) | 0.003 | 0.087 | 0.163 | 0.841 | 0.006 | 0.000 | 0.000 | |
| N | 493 | 493 | 492 | 449 | 493 | 464 | 493 | 493 |
| CHRM3 | ||||||||
| Pearson correlation | –0.016 | 0.026 | –0.008 | –0.062 | –0.126** | 1 | –0.152** | 0.008 |
| Sig. (two-tailed) | 0.732 | 0.569 | 0.867 | 0.196 | 0.006 | 0.001 | 0.864 | |
| N | 465 | 465 | 465 | 434 | 464 | 465 | 465 | 465 |
| CHRM1 | ||||||||
| Pearson correlation | –0.018 | –0.119** | 0.087 | 0.096* | 0.499** | –0.152** | 1 | 0.030 |
| Sig. (two-tailed) | 0.697 | 0.008 | 0.053 | 0.042 | 0.000 | 0.001 | 0.503 | |
| N | 494 | 494 | 493 | 450 | 493 | 465 | 494 | 494 |
| CHRNA5 | ||||||||
| Pearson correlation | 0.037 | –0.145** | –0.165** | –0.073 | 0.256** | 0.008 | 0.030 | 1 |
| Sig. (two-tailed) | 0.418 | 0.001 | 0.000 | 0.124 | 0.000 | 0.864 | 0.503 | |
| N | 494 | 494 | 493 | 450 | 493 | 465 | 494 | 494 |
| Correlations from data analysis | ||||||||
| ADRB1 | ||||||||
| Pearson correlation | 1 | –0.247** | –0.14 | 0.374** | 0.494** | –0.012 | 0.236** | 0.379** |
| Sig. (two-tailed) | 0.005 | 0.111 | 0 | 0 | 0.894 | 0.007 | 0 | |
| N | 130 | 130 | 130 | 130 | 130 | 130 | 130 | 130 |
| ADRB2 | ||||||||
| Pearson correlation | –0.247** | 1 | 0.17 | –0.308** | –0.093 | –0.098 | 0.315** | –0.383** |
| Sig. (two-tailed) | 0.005 | 0.054 | 0 | 0.295 | 0.266 | 0 | 0 | |
| N | 130 | 130 | 130 | 130 | 130 | 130 | 130 | 130 |
| ADRA2A | ||||||||
| Pearson correlation | –0.14 | 0.17 | 1 | 0.101 | –0.123 | 0.206* | –0.033 | –0.288** |
| Sig. (two-tailed) | 0.111 | 0.054 | 0.253 | 0.164 | 0.019 | 0.712 | 0.001 | |
| N | 130 | 130 | 130 | 130 | 130 | 130 | 130 | 130 |
| ADRA1A | ||||||||
| Pearson correlation | 0.374** | –0.308** | 0.101 | 1 | 0.236** | –0.046 | 0.210* | 0.048 |
| Sig. (two-tailed) | 0 | 0 | 0.253 | 0.007 | 0.602 | 0.017 | 0.588 | |
| N | 130 | 130 | 130 | 130 | 130 | 130 | 130 | 130 |
| CHRNA2 | ||||||||
| Pearson correlation | 0.494** | –0.093 | –0.123 | 0.236** | 1 | 0.064 | 0.349** | 0.294** |
| Sig. (two-tailed) | 0 | 0.295 | 0.164 | 0.007 | 0.472 | 0 | 0.001 | |
| N | 130 | 130 | 130 | 130 | 130 | 130 | 130 | 130 |
| CHRM3 | ||||||||
| Pearson correlation | –0.012 | –0.098 | 0.206* | –0.046 | 0.064 | 1 | 0.076 | –0.04 |
| Sig. (two-tailed) | 0.894 | 0.266 | 0.019 | 0.602 | 0.472 | 0.393 | 0.652 | |
| N | 130 | 130 | 130 | 130 | 130 | 130 | 130 | 130 |
| CHRM1 | ||||||||
| Pearson correlation | 0.236** | 0.315** | –0.033 | 0.210* | 0.349** | 0.076 | 1 | –0.039 |
| Sig. (two-tailed) | 0.007 | 0 | 0.712 | 0.017 | 0 | 0.393 | 0.657 | |
| N | 130 | 130 | 130 | 130 | 130 | 130 | 130 | 130 |
| CHRNA5 | ||||||||
| Pearson correlation | 0.379** | –0.383** | –0.288** | 0.048 | 0.294** | –0.04 | –0.039 | 1 |
| Sig. (two-tailed) | 0 | 0 | 0.001 | 0.588 | 0.001 | 0.652 | 0.657 | |
| N | 130 | 130 | 130 | 130 | 130 | 130 | 130 | 130 |
*, Correlation is significant at the 0.05 level (two-tailed); **, correlation is significant at the 0.01 level (two-tailed). TCGA, The Cancer Genome Atlas; ADRA, adrenoceptor alpha; ADRB, adrenoceptor beta; CHRM, cholinergic receptor, muscarinic; CHRNA, cholinergic receptor nicotinic alpha.