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. 2021 Jul;10(7):3306–3316. doi: 10.21037/tcr-21-207

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2021 Translational Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

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Apatinib inhibited cell viability and proliferation in a dose- and time-dependent manner. SRB assay showing growth curves of ASPC-1 cells (A) and PANC-1 cells (B) treated with different doses (0, 20, 40, 60, 80, 100 µM) of apatinib for different periods of time (24, 48, 72 h). Representative images (C) and summarized data (D) of a colony formation assay exhibiting the proliferation of ASPC-1 and PANC-1 cells. Data are presented as mean ± SD (n=5). *, P<0.05; **, P<0.01; ***, P<0.001 (n=3) vs. control group. SRB, sulforhodamine B.