Table 2. Cox proportional-hazard regression analysis for overall survival.

Variables	Univariate analysis				Multivariate analysis
	HR	95% CI	P value		HR	95% CI	P value
Sex	1.124	0.651–1.941	0.675
Age [60]	0.850	0.490–1.475	0.563
Differentiation	0.919	0.364–2.319	0.858
Lymphatic metastasis	1.956	1.124–3.435	0.018*		1.290	0.713–2.335	0.400
TNM stage	2.271	1.310–3.938	0.003*		2.322	1.270–4.247	0.006*
HBsAg	1.008	0.564–1.803	0.978
Liver cirrhosis	0.917	0.469–1.793	0.799
Size	1.429	0.824–2.480	0.204
SEZ6L2	2.176	1.242–3.814	0.007*		1.867	1.049–3.323	0.034*

Lymphatic metastasis, TNM stage, SEZ6L2 are included in the Multivariate analysis. *, significant difference.