Table 2. Univariate analyses of factors associated with survival in patients with HCC.

Characteristics	N (%)	RFS	OS
Age >65 years	126 (21.9)	0.719	0.005
Male sex	447 (77.7)	0.025	0.717
Heart disease	20 (3.5)	0.553	0.211
Hypertension	171 (29.7)	0.339	0.226
DM	108 (18.8)	0.842	0.028
Hyperlipidemia	35 (6.1)	0.378	0.211
Obesity	243 (42.3)	0.011	0.002
Child-Pugh B or C	29 (5.0)	0.119	0.062
MELD >10	63 (11.0)	0.581	0.096
AFP >20 ng/mL	253 (44.0)	0.009	0.006
Hypoalbuminemia	62 (10.8)	0.005	0.051
Thrombocytopenia	82 (14.3)	0.017	0.001
Major liver resection	142 (24.7)	0.143	<0.001
Anatomical resection	342 (59.5)	0.761	0.175
Operation time ≥200 min	382 (66.4)	0.094	0.135
Blood loss >500 mL	213 (37.0)	<0.001	0.003
Blood transfusion	106 (18.4)	0.008	0.002
Cirrhosis	354 (61.6)	0.008	0.101
R0	32 (5.6)	0.004	0.103
Microvascular invasion	250 (43.5)	<0.001	<0.001
Serosal invasion	147 (25.6)	0.002	0.003
ES grade		0.030	0.016
1+2	202/542 (37.3)
3+4	340/542 (62.7)
T stage		<0.001	<0.001
1+2	501 (87.1)
3+4	74 (12.9)
Major complications	68 (11.8)	0.174	0.152
HBV	539 (93.7)	0.925	0.283
NAFLD	36 (6.3)	–	–
Ki-67 >15%	175 (30.4)	0.001	<0.001
COX2 >25%	190/284 (66.9)	0.722	0.393
p53 >25%	113/456 (24.8)	0.166	0.336

HCC, hepatocellular carcinoma; RFS, recurrence-free survival; OS, overall survival; DM, diabetes mellitus; MELD, Model for End-Stage Liver Disease; AFP, α-fetoprotein; ES, Edmonson-Steiner; COX2, cyclooxygenase-2.