Table 3. Multivariable analyses of factors associated with survival in patients with HCC.

Characteristics	P value RFS	OR (95% CI)	P value OS	OR (95% CI)
Age >65 years	–	–	0.001	2.073 (1.343–3.200)
Sex	0.020	0.670 (0.478–0.940)	–	–
DM	–	–	0.368	0.759 (0.417–1.383)
Obesity	0.087	0.790 (0.604–1.034)	0.065	0.671 (0.439–1.025)
Thrombocytopenia	0.362	1.186 (0.822–1.711)	<0.001	2.704 (1.690–4.326)
AFP >20 ng/mL	0.204	1.187 (0.911–1.548)	0.105	1.403 (0.931–2.114)
Major resection	–	–	0.401	1.209 (0.777–1.880)
Blood loss >500 mL	0.260	1.195 (0.877–1.630)	0.939	0.981 (0.605–1.590)
Transfusion	0.482	1.141 (0.790–1.647)	0.128	1.462 (0.897–2.383)
R0	0.006	2.047 (1.226–3.416)	–	–
T stage	0.002	1.815 (1.255–2.626)	0.015	1.867 (1.128–3.091)
Cirrhosis	0.110	1.259 (0.949–1.668)	–	–
Microvascular invasion	<0.001	1.794 (1.375–2.340)	0.003	1.861 (1.227–2.823)
Serosal invasion	0.915	0.984 (0.732–1.323)	0.865	1.037 (0.681–1.580)
ES grade	0.944	1.010 (0.761–1.341)	0.483	1.171 (0.753–1.822)
Ki-67 >15%	0.048	1.310 (1.002–1.713)	0.023	1.586 (1.065–2.361)

HCC, hepatocellular carcinoma; RFS, recurrence-free survival; OR, odds ratio; CI, confidence interval; OS, overall survival; DM, diabetes mellitus; AFP, α-fetoprotein; ES, Edmonson-Steiner.