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. 2021 Jul;10(7):3345–3355. doi: 10.21037/tcr-21-707

Table 4. Factors associated with survival in patients with HCC associated with NAFLD.

Characteristics Local RFS Systemic RFS
Age >65 years 0.501 0.544
Male sex 0.220 0.119
Heart disease 0.453 0.513
Hypertension 0.515 0.067
DM 0.410 0.789
Hyperlipidemia 0.203 0.760
Obesity 0.110 0.920
Child-Pugh 0.735 0.715
MELD >10 0.956 0.600
AFP >20 ng/mL 0.986 0.473
Hypoalbuminemia 0.796 0.338
Thrombocytopenia 0.920 0.659
Major resection 0.852 0.263
Anatomical resection 0.178 0.459
Operation time ≥200 min 0.402 0.322
Blood loss >500 mL 0.414 0.877
Blood transfusion 0.627 0.355
Cirrhosis 0.117 0.375
R0 0.428 0.715
Microvascular invasion 0.997 0.415
Serosal invasion 0.696 0.085
ES grade 0.185 0.106
T stage 0.158 <0.001

HCC, hepatocellular carcinoma; NAFLD, non-alcoholic fatty liver disease; RFS, recurrence-free survival; DM, diabetes mellitus; MELD, Model for End-Stage Liver Disease; AFP, α-fetoprotein; ES, Edmonson-Steiner.