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. 2020 Dec;9(12):7619–7631. doi: 10.21037/tcr-20-2359

Table 2. In vitro and in vivo anti-cancer effect of selected polyphenols.

Cancer Cell type Main effects Reference
Quercetin
   Hepatocellular cancer HepG2, SMMC-7721 Inducing apoptosis, decrease tumor growth (26)
   Breast cancer MCF-7 Induction of apoptosis (27)
   Colon cancer HCT116 Inducing apoptosis (28)
   Gastric cancer BGC-823 Inducing apoptosis (29)
   Primary effusion lymphoma cancer BC3, BCBL1 and BC1 Induction of apoptosis, autophagy, inhibiting PI3K/AKT/mTOR pathway (30)
   Cervical cancer HeLa Inducing apoptosis, autophagy (31)
   Hepatocellular cancer LM3 Inducing apoptosis, G2/M cell cycle arrest, autophagy, inhibits JAK/STAT3 pathway (32)
   Pancreatic cancer PATU-8988, PANC-1 Inhibiting metastasis and STAT3 pathway (33)
   Prostate cancer PC-3 Inhibiting angiogenesis and tumor growth (34)
   Retinoblastoma Y79 Inhibits migration, angiogenesis and inducing apoptosis (35)
   Rhesus choroids-retina cancer RF/6A Inducing apoptosis, inhibits angiogenesis (36)
   Breast cancer MCF-7 Inhibits xenograft growth, angiogenesis by calcineurin/NFAT pathway (37)
   Colon cancer HT29, CT26 Inducing apoptosis, inhibits metastasis, MAPK pathway (38)
Curcumin
   Colon cancer HT29 Inducing apoptosis (39)
   Leukemia CEM, HSB2, Jurkat and Molt-4 Inducing apoptosis, Inhibiting PI3K/AKT pathway (40)
   Lung cancer A549 Induction of apoptosis, suppression of PI3K/AKT pathway (41)
   Ovarian cancer SK-OV-3, A2780 Inducing apoptosis, autophagy and inhibits AKT/mTOR/p70S6K pathway (42)
   Colon cancer HCT116, SW620 Induce autophagy (43)
   Pancreatic cancer PANC1, BxPC3 G2/M cell cycle arrest, apoptosis and autophagy (44)
   Gastric cancer AGS G2/M phase cell cycle arrest, apoptosis, Ras/ERK pathway (45)
   Prostate cancer DU145 Inhibiting metastasis (46)
   Lung cancer 801D Inhibiting metastasis (47)
   Mesothelioma RN5 Inhibits angiogenesis, tumor growth (48)
   Lung cancer NCI-H446, NCI-1688 Inhibits metastasis, angiogenesis and STAT3 pathway (49)
   Breast cancer MCF-7 Inhibits metastasis and angiogenesis (50)
   Prostate cancer LNCaP Inducing apoptosis, inhibits angiogenesis, metastasis (51)
Resveratrol
   Gastric cancer SGC7901 Inducing apoptosis (52)
   Prostate cancer TRAMP-C1, TRAMP-C2, and TRAMP-C3 Inducing apoptosis (53)
   Oral cancer SCC-VII, SCC-25, and YD-38 Inducing G2/M cell cycle arrest, apoptosis (54)
   Melanoma A375SM Inducing G2/M cell cycle arrest, apoptosis (55)
   Hepatocellular cancer MHCC97-H Autophagy, Inhibits PI3K/AKT pathway (56)
   Melanoma B16-F10, A375 Inducing apoptosis, autophagy, inhibits PI3K/AKT/mTOR pathway (57)
   Hepatocellular cancer Huh7 Inhibits metastasis, JNK pathway (58)
   Colon cancer SW480, SW620 Inhibits metastasis, AKT/GSK-3β/Snail pathway (59)
   Colorectal cancer HCT116, Caco2 Inhibiting angiogenesis (60)
   Melanoma B16 Inhibits angiogenesis (61)
   Breast cancer MDA-MB-231 Induces apoptosis, inhibits angiogenesis in vivo (62)
Kaempferol
   Ovarian cancer OVACAR-3 Inducing apoptosis, inhibition of PI3K/AKT/mTOR and STAT3 pathway (63)
   Colon cancer HT-29 Inducing apoptosis (64)
   Gastric cancer AGS, SNU-638 Induce autophagy, IRE1-JNK-CHOP and AMPKα/ULK1 pathway (65)
   Hepatocellular cancer HepG2 Inducing autophagy, ER stress-CHOP pathway (66)
   Colon cancer HT-29 G2/M cell cycle arrest (67)
   Breast cancer MDA-MB-453 Induction of apoptosis, G2/M cell cycle arrest (68)
   Lung cancer A549 Inducing apoptosis, autophagy, PI3K/AKT pathway (69)
   Osteosarcoma U-2 OS Inhibits metastasis, blocks MAPK pathway (70)
   Tongue cancer SCC-4 Inhibit metastasis, ERK pathway (71)
   Ovarian cancer OVCAR-3, A2780/CP70 Inhibits angiogenesis (72)
   Cholangiocarcinoma HCCC9810, QBC939 Inducing apoptosis, inhibits PI3K/AKT and tumor growth (73)