Table 1. Clinical and pathologic features of colorectal cancer patients.
Feature (N=100) | Variable | N | TFU of tumor | P | TFU of CAF | P | RTL | P |
---|---|---|---|---|---|---|---|---|
Age (years) | <65 | 64 | 1,535 (572–4,897) | 0.245 | 2,885 (1,873–3,913) | 0.046 | 0.73 (0.25–2.5) | 0.815 |
≥65 | 36 | 2,718 (576–7,514) | 2,317 (1,309–3,223) | 0.99 (0.28–1.87) | ||||
Gender | Male | 45 | 2,082 (457–5,779) | 0.967 | 2,600 (1,764–3,738) | 0.386 | 0.71 (0.20–2.1) | 0.406 |
Female | 55 | 1,876 (655–4,315) | 2,271 (1,575–3,337) | 0.92 (0.37–2.0) | ||||
Tumor location | Right colon | 26 | 1,292 (334–5,726) | 0.505 | 1,855 (739–2,831) | 0.127 | 1.07 (0.31–3.20) | 0.657 |
Left colon | 74 | 2,082 (616–5,486) | 2,437 (1,776–3,506) | 0.92 (0.25–1.96) | ||||
Differentiation | Well | 54 | 2,189 (691–5,779) | 0.260 | 2,437 (1767–3,542) | 0.303 | 0.94 (0.29–2.30) | 0.879 |
Moderate–poor | 46 | 1,085 (481–5,709) | 2,162 (1,268–2,993) | 0.92 (0.18–1.92) | ||||
T stage | T1-2 | 38 | 2,066 (698–6,235) | 0.643 | 2,599 (1,964–3,581) | 0.212 | 0.71 (0.25–2.53) | 0.587 |
T3-4 | 62 | 1,879 (523–5,450) | 2,254 (1,340–3,484) | 0.94 (0.29–1.96) | ||||
Lymph node metastasis | Negative | 52 | 1,820 (669–4,715) | 0.776 | 2,440 (1,764–3,463) | 0.849 | 0.74 (0.26–1.97) | 0.581 |
Positive | 48 | 2,198 (516–7,500) | 2,395 (1,529–3,508) | 0.84 (0.29–2.15) | ||||
Perineural invasion | Negative | 97 | 1,994 (626–5,508) | 0.021 | 2,451 (1,810–3,508) | 0.001 | 0.89 (0.26–2.10) | 0.577 |
Positive | 3 | 360 (130–499) | 404 (384–506) | 0.71 (0.34–0.75) | ||||
lymphovascular invasion | Negative | 90 | 2,136 (631–5,666) | 0.037 | 2,427 (1,776–3,451) | 0.815 | 0.93 (0.29–2.53) | 0.0662 |
Positive | 10 | 676 (130–1,989) | 2,173 (1,042–4,876) | 0.35 (0.13–1.07) | ||||
Distant metastases | Negative | 89 | 2,314 (684–5,802) | 0.002 | 2,550 (1,728–3,574) | 0.208 | 0.98 (0.31–2.17) | 0.020 |
Positive | 11 | 557 (130–956) | 2,156 (1,261–2,427) | 0.23 (0.08–0.89) | ||||
Dukes stage | A | 29 | 1,943 (719–5,248) | 0.023 | 2,550 (1,882–4,010) | 0.447 | 0.74 (0.22–2.07) | 0.072 |
B | 21 | 1,765 (703–5,125) | 2,368 (1,106–3,334) | 0.99 (0.32–2.68) | ||||
C | 39 | 2,759 (617–7,771) | 2,799 (1,703–3,871) | 1.08 (0.48–2.34) | ||||
D | 11 | 557 (130–956) | 2,156 (1,261–2,427) | 0.23 (0.08–0.89) |
TFU, telomere fluorescent intensity units; CAF, cancer-associated fibroblast cell; RTL, relative telomere length.