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. 2020 Jan;9(1):346–357. doi: 10.21037/tcr.2020.01.07

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2020 Translational Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

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MIER3 overexpression suppresses migration and invasion of NSCLC cells. A549 and H460 cells were transfected with pcDNA3.1-vector or pcDNA3.1-MIER3 for 24 h. (A) Cell migration was detected by wound healing assay. (B) The migration distance was quantified by Image J software, and the wound closure rate was presented. (C) Cell invasion was measured by Matrigel Transwell assay, images were magnified at ×200. (D) Invasion cells per field was presented. *, P<0.05 versus vector control. MIER3, mesoderm induction early response 1, family member 3; NSCLC, non-small cell lung cancer.