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. 2020 Jan;9(1):346–357. doi: 10.21037/tcr.2020.01.07

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2020 Translational Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

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MIER3 overexpression inhibits tumor growth in vivo. Mice were inoculated with A549 cells, which have transfected with pcDNA3.1-MIER3 or pcDNA3.1-vector. (A) Relative expression of MIER3 was detected by qRT-PCR. (B) Immunohistochemistry detected MIER3 expression in tumor tissues. (C) Tumor volumes were calculated per 5 days. (D) Image of tumors from two groups. (E) Tumor weights were measured after 35 days of injection. n=5. *, P<0.05 versus vector control. MIER3, mesoderm induction early response 1, family member 3; qRT-PCR, quantitative real-time polymerase chain reaction.