Table 2. Univariate and multivariate analyses of OS for all patients.

Variables	Univariate				Multivariate
	HR	95% CI	P value		HR	95% CI	P value
Age (≥60 vs. <60)	0.654	0.483–1.085	0.185
Sex (male vs. female)	1.255	0.906–1.740	0.172
Stage (I–II vs. III–IVA)	0.473	0.366–0.611	<0.001		0.283	0.191–0.419	<0.001
N stage (N− vs. N+)	0.689	0.535–0.887	0.004		1.91	1.300–2.805	0.001
Smoking (yes vs. no)	0.976	0.743–1.281	0.86
Drinking (yes vs. no)	0.891	0.676–1.174	0.412
Tumor length (≥5 vs. <5)	0.854	0.663–1.099	0.219
Tumor location
Upper
Middle	0.701	0.445–1.104	0.125
Lower	1.092	0.838–1.424	0.514
Differentiation
Well
Middle	0.532	0.334–0.848	0.008
Poor	0.742	0.547–0.959	0.024
NLR (≥3.14 vs. <3.14)	1.377	1.050–1.806	0.021
PNI (≥49.1 vs. <49.1)	0.505	0.391–0.652	<0.001		0.472	0.364–0.612	<0.001
PNI-NLR
0
1	0.401	0.276–0.578	<0.001		0.579	0.360–0.932	0.025
2	0.689	0.484–0.981	0.038		0.704	0.704–0.529	0.016

NLR, neutrophil to lymphocyte ratio; PNI, prognostic nutritional index; OS, overall survival.