Table 5. Analysis of factors predicting OS.
| Items | Cox’s regression model | |||
|---|---|---|---|---|
| P value | HR | 95% CI | ||
| Lower | Higher | |||
| Univariate Cox’s regression | ||||
| CXCL1 high | <0.001 | 1.889 | 1.363 | 2.618 |
| CXCL2 high | 0.015 | 1.497 | 1.080 | 2.074 |
| CXCL8 high | 0.164 | 1.266 | 0.908 | 1.763 |
| Age (>60 years) | 0.154 | 1.262 | 0.916 | 1.740 |
| Male | 0.346 | 1.189 | 0.830 | 1.704 |
| History smoke | 0.361 | 0.862 | 0.626 | 1.186 |
| History drink | 0.534 | 1.108 | 0.802 | 1.529 |
| Hypertension | 0.766 | 0.951 | 0.683 | 1.324 |
| Hyperlipidemia | 0.677 | 0.929 | 0.655 | 1.317 |
| Diabetes | 0.340 | 0.814 | 0.533 | 1.243 |
| Poor differentiation | 0.019 | 1.325 | 1.047 | 1.676 |
| Tumor size | 0.001 | 1.700 | 1.233 | 2.344 |
| LYN metastasis | <0.001 | 3.219 | 2.323 | 4.458 |
| TNM stage | <0.001 | 1.485 | 1.223 | 1.804 |
| Abnormal CEA level* | 0.002 | 1.685 | 1.205 | 2.355 |
| Forward stepwise multivariate Cox’s regression | ||||
| CXCL1 high | 0.004 | 1.628 | 1.167 | 2.273 |
| Poor differentiation | 0.029 | 1.328 | 1.029 | 1.714 |
| LYN metastasis | <0.001 | 2.983 | 2.142 | 4.154 |
| Abnormal CEA level* | 0.006 | 1.612 | 1.151 | 2.259 |
Factors with P value less than 0.05 in univariate Cox’s regression were included in forward stepwise multivariate Cox’s regression. *, normal CEA level ≤5 ng/mL and abnormal CEA level >5 ng/mL. OS, overall survival; HR, hazard ratio; CI, confidence interval; CXCL, chemokine (C-X-C motif) ligand; LYN, lymph node; CEA, carcinoembryonic antigen.