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. 2019 Sep;8(5):2005–2013. doi: 10.21037/tcr.2019.09.07

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2019 Translational Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

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Rutin-induced ROS generation in CHME cells. Flow cytometric analysis of ROS in CHME cells using DCFH-DA. Rutin generated ROS in a concentration-dependent manner in CHME cells. Untreated samples were compared with rutin-treated samples. The data presented here are the means of three independent experiments; statistical significance was assigned at *P<0.05, **P<0.01, and ***P<0.001 compared with the untreated control. ROS, reactive oxygen species; DCFH-DA, 2,7-dichlorodihydrofluorescein diacetate.