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. 2019 Sep;8(5):2005–2013. doi: 10.21037/tcr.2019.09.07

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2019 Translational Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

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Rutin-induced mitochondrial membrane potential loss and apoptosis in CHME cells. (A) Flow cytometric analysis showed that rutin induced mitochondrial membrane potential loss in a dose-dependent manner; (B) western blotting showed that rutin up-regulated P53, BAX, cytochrome c, and the activation of caspase 9 and caspase 3 and also down-regulated BCL2 and PARP1 cleavage in CHME cells, all in a dose-dependent manner. The data presented here are the means of three independent experiments; statistical significance was assigned at *P<0.05, **P<0.01, and ***P<0.001 compared with the untreated control.