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. 2019 Sep;8(5):2005–2013. doi: 10.21037/tcr.2019.09.07

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2019 Translational Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

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The knockdown of P53 abolishes the effect of rutin in human glioma CHME cells. (A) Western blot analysis of P53, cytochrome c, BAX, BCL2, caspase 9, caspase 3, and PARP1 in knockdown P53 CHME cells after treatment with various concentrations of rutin; (B) cell viability was calculated in knockdown P53 CHME cells treated with rutin; (C) western blotting showed the efficacy of siP53 in CHME cells. The data presented here are the means of three independent experiments; statistical significance was assigned at *P<0.05, **P<0.01, and ***P<0.001 compared with the untreated control.