Table 4. Multivariate analysis for clinicopathologic factors that affect the CSS and the OS.
| Analysis | Group | CSS | OS | |||||
|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |||
| Adjustment 1a | TC | Ref. | Ref. | |||||
| TC2BC | 0.236 | 0.172–0.323 | <0.001 | 1.146 | 1.06–1.238 | 0.001 | ||
| BC2TC | 0.61 | 0.499–0.747 | <0.001 | 1.634 | 1.504–1.775 | <0.001 | ||
| Adjustment 2b | TC | Ref. | Ref. | |||||
| TC2BC | 1.576 | 0.212–11.694 | 0.656 | 0.866 | 0.274–2.731 | 0.805 | ||
| BC2TC | 0.443 | 0.108–1.821 | 0.259 | 1.881 | 1.18–2.997 | 0.008 | ||
| Adjustment 3c | TC | Ref. | Ref. | |||||
| TC2BC | – | – | 0.97 | 0.631 | 0.086–4.631 | 0.651 | ||
| BC2TC | 0.388 | 0.052–2.876 | 0.355 | 1.309 | 0.558–3.069 | 0.536 | ||
a, Adjustment 1 for age and race; b, adjustment 2 for age, race, grade, histology, T-stage, N-stage, M-stage, multifocality and extension; c, adjustment 3 for age, race, grade, histology, T-stage, N-stage, M-stage, multifocality, extension, radiation and surgery. CSS, cancer-specific survival; OS, overall survival; HR, hazard ratio; CI, confidence interval; TC, thyroid cancer; BC, breast cancer; TC2BC, BC after TC; BC2TC, BC before TC.