Table 3. Univariate and multivariate analyses of factors associated with OS.
| Characteristics | Univariate analyses | Multivariate analyses | |||
|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | ||
| Age (years) | |||||
| ≤65 | Reference | ||||
| >65 | 1.53 (0.97–2.44) | 0.070 | |||
| BMI (kg/m2) | |||||
| ≤24 | Reference | ||||
| >24 | 0.78 (0.48–1.26) | 0.312 | |||
| Sex | |||||
| Male | Reference | ||||
| Female | 1.01 (0.52–1.96) | 0.989 | |||
| CCI | |||||
| ≤2 | Reference | ||||
| >2 | 0.93 (0.59–1.49) | 0.767 | |||
| T-stage | |||||
| T1 | Reference | Reference | |||
| T2 | 2.28 (1.11–4.68) | 0.025 | 2.17 (1.05–4.48) | 0.036 | |
| T3 | 3.82 (1.97–7.41) | <0.001 | 2.70 (1.35–5.39) | 0.005 | |
| T4 | 5.56 (2.86–10.81) | <0.001 | 3.18 (1.49–6.78) | 0.003 | |
| N-stage | |||||
| N0 | Reference | Reference | |||
| N+ | 3.42 (2.07–5.66) | <0.001 | 2.09 (1.17–3.73) | 0.012 | |
| M-stage | |||||
| M0 | Reference | Reference | |||
| M1 | 2.91 (1.17–7.24) | 0.020 | 2.74 (1.06–7.06) | 0.037 | |
| Grade | |||||
| Low grade | Reference | ||||
| High grade | 1.90 (0.68–5.28) | 0.221 | |||
| MLR | |||||
| ≤0.54 | Reference | Reference | |||
| >0.54 | 2.97 (1.78–4.93) | <0.001 | 2.30 (1.36–3.89) | 0.002 | |
| NLR | |||||
| ≤4.10 | Reference | Reference | |||
| >4.10 | 1.77 (1.11–2.82) | 0.016 | – | 0.777 | |
| PLR | |||||
| ≤164.63 | Reference | Reference | |||
| >164.63 | 1.93 (1.21–3.08) | 0.006 | – | 0.396 | |
HR, hazard ratio; OS, overall survival; CI, confidence interval; BMI, body mass index; CCI, comprehensive complication index; MLR, monocyte-to-lymphocyte ratio; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio.