Table 4. Univariate and multivariate analyses of factors associated with DFS.
| Characteristics | Univariate analyses | Multivariate analyses | |||
|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | ||
| Age (years) | |||||
| ≤65 | Reference | ||||
| >65 | 1.51 (0.91–2.49) | 0.108 | |||
| BMI (kg/m2) | |||||
| ≤24 | Reference | ||||
| >24 | 0.65 (0.38–1.11) | 0.114 | |||
| Sex | |||||
| Male | Reference | ||||
| Female | 0.92 (0.44–1.93) | 0.821 | |||
| CCI | |||||
| ≤2 | Reference | ||||
| >2 | 0.83 (0.50–1.39) | 0.481 | |||
| T-stage | |||||
| Ta/Tis /T1 | Reference | Reference | |||
| T2 | 4.12 (1.72–9.85) | 0.001 | 4.00 (1.67–9.60) | 0.002 | |
| T3 | 6.73 (2.97–15.25) | <0.001 | 4.76 (2.05–11.08) | <0.001 | |
| T4 | 9.59 (4.20–21.92) | <0.001 | 5.46 (2.20–13.58) | <0.001 | |
| N-stage | |||||
| N0 | Reference | Reference | |||
| N+ | 3.79 (2.22–6.45) | <0.001 | 2.16 (1.18–3.96) | 0.013 | |
| M-stage | |||||
| M0 | Reference | Reference | |||
| M1 | 3.55 (1.42–8.90) | 0.007 | 3.46 (1.32–9.08) | 0.012 | |
| Grade | |||||
| Low grade | Reference | ||||
| High grade | 2.02 (0.63–6.49) | 0.236 | |||
| MLR | |||||
| ≤0.54 | Reference | Reference | |||
| >0.54 | 2.92 (1.69–5.06) | <0.001 | 2.13 (1.21–3.75) | 0.009 | |
| NLR | |||||
| ≤4.10 | Reference | Reference | |||
| >4.10 | 1.80 (1.09–2.96) | 0.021 | – | 0.784 | |
| PLR | |||||
| ≤164.63 | Reference | Reference | |||
| >164.63 | 2.03 (1.23–3.35) | 0.006 | – | 0.371 | |
HR, hazard ratio; DFS, disease-free survival; CI, confidence interval; BMI, body mass index; CCI, comprehensive complication index; MLR, monocyte-to-lymphocyte ratio; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio.