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. 2021 Jun;10(6):2725–2737. doi: 10.21037/tcr-21-236

Figure 7.

Figure 7

How editing affects mRNA splicing and translation? (A) A-to-I(G) editing could lead to the gain or loss of splicing sites, and thus altering gene length; (B) two editing sites in the intron of ADAR1 are found. These two sites cause the gain of splicing sites. The editing ratios are higher in tumor samples of all patients compared to normal samples; (C) globally, the translation efficiency (TE) of genes is negatively correlated with mRNA length.