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. 2021 Jun;10(6):2725–2737. doi: 10.21037/tcr-21-236

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2021 Translational Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

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The inference of translation regulation conferred by RNA editing. (A) Two editing sites in oncogenes MDM4 and MDM2. The two sites are located in 3'UTR and cause the abolishment of microRNA binding sites. The editing ratios of the two sites are higher in tumor samples of all patients compared to normal samples. (B) The translation efficiency (TE) of oncogenes MDM4 and MDM2 in tumor and normal samples. P values are calculated by KS tests. ***P value <0.001. (C) The gene expression (RPKM) and translation efficiency (TE) of different gene sets. Other means the total genes with oncogenes and tumor suppressor genes (TSG) removed. P values are calculated by KS tests. ***P value <0.001.