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. 2019 Oct;8(6):2425–2438. doi: 10.21037/tcr.2019.09.61

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2019 Translational Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

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GO function and KEGG pathway enrichment analysis of DEGs identified in HCC827-ER3 cells treated with combination of erlotinib and MGCD265. (A,C) The top biological process terms of GO analysis and the top KEGG signaling pathways enriched amongst the upregulated genes. (B,D) The top biological process terms and the top KEGG signaling pathways enriched amongst the downregulated genes. The y-axis indicates functional groups by GO category. The x-axis indicates –log (P value) of GO category. Significance is expressed as the P value calculated using Fisher’s exact test (P<0.05). GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; DEGs, differentially-expressed genes.