Table S2. Expression level of upregulated DEGs (vs. control) enriched in multiple biological processes.
| Gene symbol | Fold change (treatment vs. control) | ||
|---|---|---|---|
| MGCD265 + erlotinib | Erlotinib | MGCD265 | |
| Positive regulation of apoptotic process | |||
| BCL6 | 1.570810516 | 1.500691193 | 1 |
| BNIP3L | 1.396316619 | 1 | 1.280790364 |
| BCL2L1 | 1.693605198 | 1 | 1 |
| ARHGEF2 | 1.858789066 | 1.631498432 | 1 |
| SOS2 | 1.433273931 | 1.245688175 | 1 |
| SOX4 | 1.529794862 | 1.246951616 | 1 |
| TIAM | 1.219890263 | 1 | 1 |
| ATF4 | 1.99619867 | 1 | 1 |
| APBB2 | 1.290583732 | 1 | 1 |
| ANKRD1 | 1.599681138 | 1 | 1.5471155 |
| APH1A | 1.333287179 | 1 | 1 |
| CDK19 | 1.33659376 | 1 | 1 |
| DUSP6 | 1.567727508 | 1.465150443 | 1 |
| ECT2 | 1.300534572 | 1 | 1 |
| GADD45B | 1.678462013 | 1 | 1 |
| HMOX1 | 1.606346423 | 1 | 1 |
| HMGB1 | 1.398352809 | 1.429730499 | 1 |
| HIP1R | 1.271504711 | 1 | 1 |
| IP6K2 | 1.423977161 | 1 | 1 |
| JMY | 1.312008281 | 1.349909538 | 1 |
| NET1 | 1.256360135 | 1.211107554 | 1 |
| NUPR1 | 3.565986854 | 3.455794632 | 1 |
| PNMA2 | 1.317620231 | 1 | 1 |
| PMAIP1 | 1.273440546 | 1 | 1 |
| PSEN1 | 1.321673666 | 1.231496166 | 1 |
| PTGS2 | 1.509385178 | 1.501834979 | 1 |
| PRMT2 | 1.453487499 | 1 | 1 |
| RPS6KA2 | 1.597029169 | 1.604806177 | 1 |
| SAV1 | 1.200108843 | 1 | 1 |
| SQSTM1 | 1.470799563 | 1 | 1 |
| SIAH1 | 2.066825829 | 1 | 1 |
| TXNIP | 1.999955437 | 1.855142834 | 1 |
| TP53 | 1.230938025 | 1 | 1 |
| Cell cycle arrest | |||
| DDIT3 | 2.649910503 | 2.099035989 | 1 |
| HBP1 | 1.801522281 | 1.713758259 | 1 |
| SMAD3 | 1.310052368 | 1 | 1 |
| APBB2 | 1.290583732 | 1 | 1 |
| CDKN1A | 1.463461144 | 1 | 1 |
| CDKN2B | 1.346878936 | 1 | 1 |
| ERN1 | 1.514346277 | 1.424297261 | 1 |
| FOXO4 | 1.429176125 | 1 | 1 |
| JMY | 1.312008281 | 1.349909538 | 1 |
| MFN2 | 1.514552582 | 1 | 1 |
| PPP1R15A | 1.291899504 | 1.206875857 | 1 |
| TSC2 | 1.304248887 | 1 | 1 |
| TP53 | 1.230938025 | 1 | 1 |
| MYC | 1.410985277 | 1.266748014 | 1 |
| Negative regulation of ERK1 and ERK2 cascade | |||
| ERRFI1 | 1.261886742 | 1.289822014 | 1 |
| KLF4 | 1.599439716 | 1.347331821 | 1 |
| RAPGEF1 | 1.521917605 | 1 | 1 |
| XBP1 | 1.869085583 | 1.5056869 | 1 |
| ATF3 | 1.708230933 | 1 | 1 |
| DUSP4 | 1.296108342 | 1 | 1 |
| DUSP6 | 1.567727508 | 1.465150443 | 1 |
| EZR | 1.476568899 | 1.544670372 | 1.510260914 |
| LIF | 1.295467052 | 1 | 1 |
| SPRY4 | 1.334091553 | 1 | 1 |
| Intrinsic apoptotic signaling pathway in response to ER stress | |||
| DDIT3 | 2.649910503 | 2.099035989 | 1 |
| HBP1 | 1.801522281 | 1.713758259 | 1 |
| SMAD3 | 1.310052368 | 1 | 1 |
| APBB2 | 1.290583732 | 1 | 1 |
| CDKN1A | 1.463461144 | 1 | 1 |
| CDKN2B | 1.346878936 | 1 | 1 |
| ERN1 | 1.514346277 | 1.424297261 | 1 |
| FOXO4 | 1.429176125 | 1 | 1 |
| JMY | 1.312008281 | 1.349909538 | 1 |
| MFN2 | 1.514552582 | 1 | 1 |
| PPP1R15A | 1.291899504 | 1.206875857 | 1 |
| TSC2 | 1.304248887 | 1 | 1 |
| TP53 | 1.230938025 | 1 | 1 |
| MYC | 1.410985277 | 1.266748014 | 1 |