Table S3. Expression level of downregulated DEGs (vs. control) enriched in multiple biological processes.
| Gene symbol | Fold change (treatment vs. control) | ||
|---|---|---|---|
| MGCD265 + erlotinib | Erlotinib | MGCD265 | |
| Cell division | |||
| ATAD3B | 0.699796587 | 0.717925923 | 1 |
| CABLES2 | 0.750020498 | 1 | 1 |
| DIS3L2 | 0.53274437 | 1 | 1 |
| LIG4 | 0.650349446 | 1 | 1 |
| DSN1 | 0.659154236 | 1 | 1 |
| ERCC6L | 0.696356995 | 1 | 1 |
| FBXO5 | 0.609049566 | 0.695204352 | 1 |
| HAUS6 | 0.824159456 | 0.780089206 | 1 |
| NSUN2 | 0.757933959 | 0.774571282 | 1 |
| PDS5B | 0.793715408 | 0.767906154 | 1 |
| PHF13 | 0.770399369 | 0.781579307 | 1 |
| ZWINT | 0.714788883 | 1 | 1 |
| CDC20 | 0.787424854 | 1 | 1 |
| CDC25A | 0.598816259 | 0.65588207 | 1 |
| CDC6 | 0.638133071 | 0.724462682 | 1 |
| CDC7 | 0.819192058 | 0.824801908 | 1 |
| CDCA2 | 0.724016995 | 0.683917853 | 1 |
| CDCA5 | 0.598816259 | 0.789532223 | 1 |
| CENPT | 0.747000771 | 1 | 1 |
| CCNA2 | 0.796728486 | 0.828706336 | 1 |
| CCND3 | 0.597693581 | 0.689911532 | 1 |
| CCNE2 | 0.601208611 | 0.627989732 | 1 |
| CCNF | 0.811518208 | 1 | 1 |
| CDK2 | 0.747170127 | 0.785909293 | 1 |
| CDK4 | 0.809001405 | 1 | 1 |
| CDK6 | 0.779894059 | 0.796641826 | 1 |
| FAM64A | 0.778219456 | 1 | 1 |
| FIGN | 0.726964207 | 1 | 1 |
| HELLS | 0.763870624 | 0.770328066 | 1 |
| KLHL42 | 0.799134241 | 0.821392492 | 1 |
| KIF18B | 0.833116897 | 1 | 1 |
| KIF20B | 0.711042036 | 1 | 1 |
| KIFC1 | 0.770301058 | 1 | 1 |
| MASTL | 0.496263385 | 0.704866858 | 1 |
| MCM5 | 0.809011572 | 1 | 1 |
| NCAPG | 0.774262647 | 0.754577509 | 1 |
| NCAPH | 0.770217973 | 1 | 1 |
| NCAPD3 | 0.748339557 | 0.798079695 | 1 |
| NUDC | 0.77975868 | 1 | 1 |
| PRPF40A | 0.784792564 | 1 | 1 |
| PRKCE | 0.808702222 | 1 | 1 |
| RCC1 | 0.653393194 | 1 | 1 |
| SEPT | 0.79834066 | 0.796708043 | 1 |
| SKA3 | 0.750522021 | 1 | 1 |
| SPDL1 | 0.716440826 | 1 | 1 |
| SMC4 | 0.687627705 | 1 | 1 |
| TACC3 | 0.820450543 | 1 | 1 |
| TUBA1B | 0.707870107 | 1 | 1 |
| USP37 | 0.801775898 | 0.829695094 | 1 |
| VRK1 | 0.813398638 | 0.7946735 | 1 |
| VPS4A | 0.830147228 | 1 | 1 |
| ZWILCH | 0.701666802 | 1 | 1 |
| DNA replication | |||
| BARD1 | 0.637203915 | 0.759313554 | 1 |
| BRIP1 | 0.630692829 | 0.652681375 | 1 |
| LIG4 | 0.650349446 | 1 | 1 |
| POLA2 | 0.673108697 | 0.802900219 | 1 |
| POLD3 | 0.793045387 | 0.822547354 | 1 |
| POLE | 0.808760222 | 1 | 1 |
| DSCC1 | 0.672814491 | 0.705769428 | 1 |
| GINS2 | 0.635446077 | 0.730979491 | 1 |
| GINS3 | 0.767525935 | 0.784890792 | 1 |
| RAD1 | 0.784182393 | 0.781117533 | 1 |
| RBM14 | 0.726254055 | 0.751910676 | 1 |
| TICRR | 0.739873815 | 0.775313361 | 1 |
| CDC25A | 0.598816259 | 0.65588207 | 1 |
| CDC45 | 0.78138931 | 0.786718155 | 1 |
| CDC6 | 0.638133071 | 0.724462682 | 1 |
| CDC7 | 0.819192058 | 0.824801908 | 1 |
| CHAF1A | 0.725619903 | 0.749045337 | 1 |
| CHAF1B | 0.695921621 | 0.73503896 | 1 |
| CHTF18 | 0.720097815 | 1 | 1 |
| CLSPN | 0.515666821 | 0.545984201 | 1 |
| CDK2 | 0.747170127 | 0.785909293 | 1 |
| DTL | 0.671447943 | 0.728623805 | 1 |
| DUT | 0.808708758 | 1 | 1 |
| EXO1 | 0.600585149 | 0.668348878 | 1 |
| FEN1 | 0.646919176 | 0.673411842 | 1 |
| MCM10 | 0.579587004 | 0.673882478 | 1 |
| MCM4 | 0.796587629 | 0.786586647 | 1 |
| MCM5 | 0.809011572 | 1 | 1 |
| NOL8 | 0.628457322 | 1 | 1 |
| NUP98 | 0.692971474 | 1 | 1 |
| ORC1 | 0.651124396 | 0.75489963 | 1 |
| ORC6 | 0.74897745 | 0.713235537 | 1 |
| PCNA | 0.730196232 | 0.752830213 | 1 |
| RTEL1 | 0.818759095 | 0.816647045 | 0.795584455 |
| RFC4 | 0.825145898 | 1 | 1 |
| RFC5 | 0.657860132 | 0.739748932 | 1 |
| RRM1 | 0.785388749 | 0.832808076 | 1 |
| RRM2 | 0.637552411 | 0.685144139 | 1 |
| DNA repair | |||
| BCCIP | 0.748416646 | 1 | 1 |
| POLE | 0.808760222 | 1 | 1 |
| POLQ | 0.77025084 | 0.794883047 | 1 |
| DOT1L | 0.6937146 | 0.793343611 | 1 |
| FANCA | 0.644724544 | 1 | 1 |
| FANCG | 0.588956357 | 1 | 1 |
| FANCI | 0.799174667 | 0.829467802 | 1 |
| PDS5B | 0.793715408 | 0.767906154 | 1 |
| RAD1 | 0.784182393 | 0.781117533 | 1 |
| RAD18 | 0.75267768 | 0.716666737 | 1 |
| RAD51AP1 | 0.695368416 | 1 | 0.697240398 |
| RAD54L | 0.721212552 | 0.728997562 | 1 |
| RBM14 | 0.726254055 | 0.751910676 | 1 |
| TICRR | 0.739873815 | 0.775313361 | 1 |
| CHAF1A | 0.725619903 | 0.749045337 | 1 |
| CLSPN | 0.515666821 | 0.751910437 | 1 |
| CDK2 | 0.747170127 | 0.785909293 | 1 |
| EME2 | 0.799044431 | 1 | 1 |
| EXO1 | 0.600585149 | 0.668348878 | 1 |
| FEN1 | 0.646919176 | 0.673411842 | 1 |
| MCRS1 | 0.830340008 | 1 | 1 |
| MSH6 | 0.666630119 | 0.663940906 | 1 |
| NABP1 | 0.617556529 | 0.567306751 | 1 |
| RTEL1 | 0.818759095 | 0.816647045 | 0.795584455 |
| RFC5 | 0.657860132 | 0.739748932 | 1 |
| RFWD3 | 0.803087075 | 0.816565228 | 1 |
| TEX15 | 0.775624104 | 0.779854234 | 1 |
| UBE2T | 0.748803457 | 0.720974576 | 1 |
| Actin cytoskeleton reorganization | |||
| BCCIP | 0.748416646 | 1 | 1 |
| POLE | 0.808760222 | 1 | 1 |
| FARP2 | 0.811762735 | 1 | 1 |
| MICALL2 | 0.661973595 | 1 | 1 |
| TNIK | 0.780659561 | 1 | 1 |
| CTTN | 0.641550617 | 1 | 1 |
| EZR | 0.803732687 | 0.757486198 | 1 |
| FLNA | 0.826785759 | 1 | 1 |
| PIP5K1A | 0.626792059 | 1 | 1 |