Table S4. Expression level of upregulated DEGs (vs. control) enriched in multiple KEGG pathways.
| Gene symbol | Fold change (treatment vs. control) | ||
|---|---|---|---|
| MGCD265 + erlotinib | Erlotinib | MGCD265 | |
| P53 signaling pathway | |||
| BBC3 | 1.775598694 | 1 | 1 |
| CASP8 | 1.50509795 | 1.714538463 | 1 |
| CASP9 | 1.513227018 | 1 | 1 |
| CCNG1 | 1.775598694 | 1.233975191 | 1 |
| CCNG2 | 2.263213411 | 1.974321134 | 1 |
| CDKN1A | 1.463461144 | 1 | 1 |
| GADD45B | 1.678462013 | 1 | 1 |
| PMAIP1 | 1.273440546 | 1 | 1 |
| RRM2B | 1.353963073 | 1 | 1 |
| SESN2 | 6.626958929 | 5.933017006 | 1 |
| SIAH1 | 2.066825829 | 1 | 1 |
| TSC2 | 1.304248887 | 1 | 1 |
| TP53 | 1.230938025 | 1 | 1 |
| Apoptosis | |||
| BCL2L1 | 1.693605198 | 1 | 1 |
| CFLAR | 1.322209947 | 1 | 1 |
| TNFRSF1A | 1.392397204 | 1 | 1 |
| CASP8 | 1.50509795 | 1.714538463 | 1 |
| CASP9 | 1.513227018 | 1 | 1 |
| IKBKB | 1.529761794 | 1.37112148 | 1.457373682 |
| PIK3CA | 1.31888819 | 1 | 1 |
| TP53 | 1.230938025 | 1 | 1 |
| Cell cycle | |||
| BUB1 | 1.211254334 | 1 | 1 |
| RBL2 | 1.524049945 | 1 | 1 |
| SMAD2 | 1.294697918 | 1 | 1 |
| SMAD3 | 1.310052368 | 1 | 1 |
| CDC14A | 1.39217711 | 1 | 1 |
| CDC14B | 1.205490294 | 1.217160462 | 1 |
| CDKN1A | 1.463461144 | 1 | 1 |
| CDKN2B | 1.346878936 | 1 | 1 |
| GADD45B | 1.678462013 | 1 | 1 |
| STAG2 | 1.233069452 | 1 | 1 |
| TP53 | 1.230938025 | 1 | 1 |
| MYC | 1.410985277 | 1.266748014 | 1 |
| FoXO signaling pathway | |||
| BCL6 | 1.570810516 | 1.500691193 | 1 |
| FBXO25 | 1.442974414 | 1.42794837 | 1 |
| FBXO32 | 1.604190926 | 1.466903076 | 1 |
| GABARAPL1 | 1.587151943 | 1.524525299 | 1 |
| RBL2 | 1.524049945 | 1 | 1 |
| SMAD2 | 1.294697918 | 1 | 1 |
| SMAD3 | 1.310052368 | 1 | 1 |
| SOS2 | 1 | 1.245688175 | 1 |
| CSNK1E | 1.380889371 | 1 | 1 |
| CCNG2 | 2.263213411 | 1.974321134 | 1 |
| CDKN1A | 1.463461144 | 1 | 1 |
| FOXO4 | 1.429176125 | 1 | 1 |
| GADD45B | 1.678462013 | 1 | 1 |
| IKBKB | 1.529761794 | 1.37112148 | 1.457373682 |
| IRS2 | 1.385004242 | 1.331280376 | 1 |
| PIK3CA | 1.31888819 | 1 | 1 |
| PCK2 | 3.853122264 | 4.037367457 | 1 |
| Hippo signaling | |||
| BBC3 | 1.775598694 | 1 | 1 |
| SMAD2 | 1.294697918 | 1 | 1 |
| SMAD3 | 1.310052368 | 1 | 1 |
| AJUBA | 1.873377925 | 1.67385878 | 1 |
| AXIN1 | 1.250607347 | 1 | 1 |
| CSNK1E | 1.380889371 | 1 | 1 |
| CTGF | 1.538758842 | 1 | 1.428814977 |
| DLG3 | 1.512565821 | 1.296332083 | 1 |
| FZD7 | 1.342673277 | 1 | 1 |
| ITGB2 | 1.572901939 | 1 | 1 |
| PARD3 | 1.250711844 | 1 | 1 |
| SAV1 | 1.200108843 | 1 | 1 |
| MYC | 1.410985277 | 1.266748014 | 1 |