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. 2021 Jun;10(6):2738–2746. doi: 10.21037/tcr-20-3385

Table 1. Univariate analysis and multivariate analysis in NCHCC.

Variables Univariate analysis Multivariate analysis
HR (95% CI) P value HR (95% CI) P value
Age (≥60) 1.06 (0.57–1.95) 0.86
Gender (male) 0.82 (0.45–1.49) 0.52
Family cancer history (yes) 1.72 (0.95–3.13) 0.07 1.78 (0.93–3.43) 0.08
Serum AFP level (≥400) 0.95 (0.43–2.10) 0.90
Child-Pugh classification (B/A) 1.13 (0.39–3.22) 0.83
Pathologic stage (III + IV/I + II) 1.72 (0.93–3.18) 0.08 3.13 (0.34–28.67) 0.31
T stage (T3 + T4 + Tx/T1 + T2) 1.99 (1.09–3.63) 0.03 0.46 (0.05–4.36) 0.50
N stage (N1 + N2 + Nx/N0) 2.15 (1.14–4.04) 0.02 1.35 (0.53–3.48) 0.53
M stage (M1 + Mx/M0) 2.52 (1.33–4.78) <0.01 2.95 (1.16–7.48) 0.02
Vessels in tumor (Micro + Macro/none) 1.12 (0.57–2.20) 0.75
Recurrence (yes) 1.37 (0.75–2.50) 0.37
SOX9 (high expression) 2.20 (1.16–4.16) 0.02 2.23 (1.07–4.62) 0.03

NCHCC, noncirrhotic hepatocellular carcinoma; HR, hazard ratio; CI, confidence interval; AFP, α-fetoprotein; Micro, microvessels; Macro, macrovessels; SOX9, Sex-Determining Region Y-Box 9.