Table 4. Univariate and multivariate analysis in all patients.

	Univariate analysis					Multivariate analysis
	P	Hazard ratio	95.0% CI			P	Hazard ratio	95.0% CI
			Lower	Upper				Lower	Upper
LNR group	0.000					0.000
LNR A	Ref					Ref
LNR B	0.000	1.725	1.420	2.096		0.000	1.784	1.379	2.308
LNR C	0.000
Year interval	Ref
1998–2000	0.008	0.739	0.591	0.923
2001–2007	0.000	0.561	0.432	0.728
2008–2014	0.316
Race	Ref
White	0.940	1.013	0.725	1.416
Black	0.132	0.751	0.517	1.091
Other	0.004
Age group	Ref
≤65	0.004	1.325	1.092	1.609
>65	0.489
Sex	Ref
Male	0.489	1.070	0.883	1.297
Female	0.446
Histologic type	Ref
IPMN	0.446	1.069	0.901	1.268
SPN	0.208
MCN	Ref
SCN	0.036	0.297	0.095	0.927
Tumor site	0.727	1.057	0.775	1.442
Head	0.992	0.000	0.000	0.000
Body/tail	0.494
Other	Ref
Overlapping	0.575	1.072	0.841	1.366
Surgery	0.295	1.363	0.764	2.430
TP	0.357	0.812	0.521	1.265
PP	0.831
Chemo	Ref
No	0.831	0. 970	0.736	1.279
Yes	0.000					0.000
T stage	Ref					Ref
T1	0.000	0.627	0.514	0.763		0.000	0.534	0.402	0.708
T2	0.005					0.069
T3	Ref					Ref
T4	0.101	1.318	0.947	1.835		0.274	1.296	.814	2.063
RNE4	0.170	1.262	0.905	1.759		0.237	1.329	.829	2.130
1–5	0.001	2.591	1.538	4.366		0.009	2.320	1.229	4.378
6–10	0.007
11–16	Ref
≥17	0.219	0.830	0.616	1.117
RNP	0.039	0.727	0.537	0.984
0	0.001	0.616	0.461	0.824
1–2	00.051
≥3	Ref
N stage	0.051	1.214	0.999	1.474
N0	0.219
N1	Ref
N2	0.219	1.139	.925	1.402
Metastasis	0.000					0.028
M0	Ref					Ref
M1	0.000	2.310	1.538	3.468		0.028	1.706	1.058	2.751
Grade	0.000					0.004
I	Ref					Ref
II	0.000	1.759	1.293	2.391		0.002	1.825	1.245	2.674
III/VI	0.000	1.911	1.384	2.639		0.002	1.898	1.264	2.851

LNR, lymph node ratio; RNP, the number of positive regional lymph nodes; RNE, regional nodes examined; LNR A, 0; LNR B, ≤0.2; LNR C, >0.2; IPMN, intraductal papillary mucinous neoplasms, MCN, mucinous cystic neoplasms, SCN, serous cystadenomas, SPN, solid pseudopapillary neoplasms; TP, total pancreatectomy, PP, Partial pancreatectomy.