Table 5. Univariate and multivariate analysis in node-positive patients.

	Univariate analysis					Multivariate analysis
	P	Hazard ratio	95.0% CI			P	Hazard ratio	95.0% CI
			Lower	Upper				Lower	Upper
LNR group	0.000					0.000
LNR B	Ref					Ref
LNR C	0.000	1.725	1.420	2.096		0.000	1.784	1.379	2.308
Year interval	0.000
1998–2000	Ref
2001–2007	0.008	0.739	0.591	0.923
2008–2014	0.000	0.561	0.432	0.728
Race	0.316
White	Ref
Black	0.940	1.013	0.725	1.416
Other	0.132	0.751	0.517	1.091
Age group	0.004
≤65	Ref
>65	0.004	1.325	1.092	1.609
Sex	0.489
Male	Ref
Female	0.489	1.070	0.883	1.297
Marital status	0.446
Married	Ref
Other	0.446	1.069	0.901	1.268
Histologic type	0.208
IPMN	Ref
SPN	0.036	0.297	0.095	0.927
MCN	0.727	1.057	0.775	1.442
SCN	0.992	0.000	0.000	0.000
Tumor site	0.494
Head	Ref
Body/tail	0.575	1.072	0.841	1.366
Other	0.295	1.363	0.764	2.430
Overlapping	0.357	0.812	0.521	1.265
Surgery	0.831
TP	Ref
PP	0.831	0. 970	0.736	1.279
Chemo	0.000					0.000
No	Ref					Ref
Yes	0.000	0.627	0.514	0.763		0.000	0.534	0.402	0.708
T stage	0.005					0.069
T1	Ref					Ref
T2	0.101	1.318	0.947	1.835		0.274	1.296	.814	2.063
T3	0.170	1.262	0.905	1.759		0.237	1.329	.829	2.130
T4	0.001	2.591	1.538	4.366		0.009	2.320	1.229	4.378
RNE4	0.007
1–5	Ref
6–10	0.219	0.830	0.616	1.117
11–16	0.039	0.727	0.537	0.984
≥17	0.001	0.616	0.461	0.824
RNP	0.051
1–2	Ref
≥3	0.051	1.214	0.999	1.474
N stage	0.219
N1	Ref
N2	0.219	1.139	.925	1.402
Metastasis	0.000					0.028
M0	Ref					Ref
M1	0.000	2.310	1.538	3.468		0.028	1.706	1.058	2.751
Grade	0.000					0.004
I	Ref					Ref
II	0.000	1.759	1.293	2.391		0.002	1.825	1.245	2.674
III/VI	0.000	1.911	1.384	2.639		0.002	1.898	1.264	2.851

LNR, lymph node ratio; RNP, the number of positive regional lymph nodes; RNE, regional nodes examined; LNR B, ≤0.2; LNR C, >0.2; IPMN, intraductal papillary mucinous neoplasms; MCN, mucinous cystic neoplasms; SCN, serous cystadenomas; SPN, solid pseudopapillary neoplasms; TP, total pancreatectomy; PP, partial pancreatectomy.