Table 3. Comparison of CellSearch and “CytoploRare Detection Kit” in the diagnosis of lung cancers.

Features	CellSearch (16)	CytoploRare Detection Kit
Required blood sample volume	7.5 mL	3 mL
Principle of CTC enrichment	EpCAM-based positive enrichment	Negative enrichment
Detection of CTC	Fluorescent immunostaining (CD45−, cytokeratin+, DAPI−)	Ligand-targeted PCR (FRα)
Clinical application	FDA-approved for assessment of prognosis of patients with metastatic breast, colorectal, and prostate cancer	CFDA-approved for assisting in diagnosis and management of lung cancer
Detection rate in lung cancer	22.5% (23)	78.7%

CTC, circulating tumor cell; PCR, polymerase chain reaction; FRα, folate receptor alpha.