Table 2. Univariable and multivariable analysis of risk factors of OS after hepatectomy.
| Variable | Univariable analysis | Multivariable analysis | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | ||
| PDL1 expression | 1.1 | 0.576–2.101 | 0.774 | – | – | – | |
| HDAC9 expression | 1.389 | 0.724–2.664 | 0.322 | – | – | – | |
| HDAC9 + PDL1 expression | 2.115 | 1.101–4.062 | 0.024 | 2.164 | 1.1–4.257 | 0.025 | |
| HDAC2 expression | 1.011 | 0.53–1.927 | 0.973 | – | – | – | |
| HDAC2 + PDL1 expression | 0.993 | 0.498–1.977 | 0.983 | – | – | – | |
| Age, year | 0.814 | 0.427–1.552 | 0.532 | – | – | – | |
| Gender, male vs. female | 2.112 | 0.508–8.785 | 0.304 | – | – | – | |
| Tumor size, cm | 5.784 | 2.247–14.892 | 0 | 4.108 | 1.536–10.984 | 0.005 | |
| AFP, μg/L | 1.569 | 0.689–3.573 | 0.284 | – | – | – | |
| Distant metastasis, yes vs. no | 5.912 | 2.836–12.323 | 0 | 2.409 | 1.101–5.273 | 0.028 | |
| Microvascular invasion, yes vs. no | 3.648 | 1.764–7.547 | 0 | 2.701 | 1.265–5.769 | 0.01 | |
| Involucrum, complete vs. incomplete | 0.495 | 0.239–1.023 | 0.058 | – | – | – | |
| HBV infection, yes vs. no | 0.621 | 0.3–1.283 | 0.198 | – | – | – | |
| Cirrhosis, yes vs. no | 0.857 | 0.449–1.634 | 0.639 | – | – | – | |
| Differentiation, III/IV vs. I/II | 0.427 | 0.151–1.205 | 0.108 | – | – | – | |
HR, hazard ratio; CI, confidence interval; OS, overall survival.