Table 1. SBRT studies in early breast cancer.
| Author | Patients | Dose | Toxicities | Local control rates | PFS | Follow-up | Age (years) |
|---|---|---|---|---|---|---|---|
| Bondiau (16) | 28 | Conventional whole breast irradiation (50 Gy, 25 f) + single dose SBRT 8 Gy | 7% grade 2 toxicity. No grade >3 toxicity | 96% | 93% | 38 months (21.3–69.1 months) | 60.5 (43–82 years) |
| Vermeulen (17) | 9 | 30 Gy, 5 f; 34 Gy, 10 f | 44% grade 1 edema. No acute lung toxicity | – | – | 7 months (4–26 months) | 56 (46–68 years) |
| Lozza (18) | 20 | 30 Gy, 5 f | No > grade 2 skin toxicity. No acute lung toxicity | 100% | 100% | 27.7 months (25.7–32.0) | More than 45 |
| Obayomi-Davies (19) | 10 | 30 Gy, 5 f | No lung, heart, chest wall toxicity. 10% grade 1 late skin toxicity | 100% | 100% | 1.3 years | 61 (48–77 years) |
| Livi (20) | 260 | 30 Gy, 5 f | 18% grade 1 acute skin toxicity, 2% acute grade 2 skin toxicity. No grade 2 late skin toxicity. No other toxicity | 99% | 97% | 5 years | More than 40 |
| Rahimi (21) | 75 | 30 to 40 Gy, 5 f | 14.6% acute grade 1 dermatitis 1.3% acute grade 2 and 3 dermatitis. 13% fat necrosis. 12% late grade 1 hyperpigmentation | 100% | 100% | 26.1 months (4.4–56.1) | 62 (45–79 years) |
Gy, Gray; f, fractions; PFS, progression free survival.