Table 2. SBRT neo-adjuvant studies in early breast cancer.
| Authors | Patients | Dose | Toxicities | Local control | Follow-up |
|---|---|---|---|---|---|
| Bondiau 2009 (22) | 6 | 19.5 to 22.5 Gy, 3f + adjuvant conventional whole breast irradiation | No skin toxicity | 33% pathological complete response; 66% pathological partial response | – |
| Bondiau 2013 (23) | 25 | 19.5, 22.5, 25.5, 28.5, 31.5 Gy, 3 f | One grade 3 skin toxicity | 100% | 30 months |
| Blitzblau, Horton et al. 2015 (24-26) | 32 | Single dose: 15, 18, 21 Gy | No skin toxicity > grade 3 | – | 23 months |
Gy, Gray; f, fractions.