Table 3. Factors associated with overall mortality according to Cox Proportional Hazard model in the patients who underwent curative hepatic resection for HCC.
| Variable | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | ||
| Old age (≥65 years) | 2.167 (1.331–3.526) | 0.002 | 1.576 (0.896–2.773) | 0.114 | |
| Male sex | 1.547 (0.863–2.773) | 0.143 | – | – | |
| Obesity (BMI ≥25 kg/m2) | 0.982 (0.609–1.582) | 0.940 | – | – | |
| Viral hepatitis (HBV or HCV) | 0.673 (0.369–1.227) | 0.196 | – | – | |
| Low platelet count (<100×103/mL) | 2.531 (1.478–4.332) | 0.001 | 3.073 (1.726–5.472) | <0.001 | |
| Low albumin (<3.5 g/dL) | 1.770 (0.811–3.867) | 0.152 | – | – | |
| High MELD-Na score (≥8) | 2.087 (1.283–3.395) | 0.003 | 1.868 (1.127–3.096) | 0.015 | |
| High AFP (≥20 ng/mL) | 0.933 (0.586–1.483) | 0.769 | – | – | |
| TNM stage II + III | 2.376 (1.452–3.887) | 0.001 | 2.466 (1.484–4.095) | <0.001 | |
| Psoas muscle index, cm2/m2 (<3.33 for male, 2.38 for female) | 2.404 (1.433-4.034) | 0.001 | 2.245 (1.021–4.937) | 0.044 | |
| Psoas muscle attenuation, HU (<46.08 for male, 48.42 for female) | 1.754 (1.046–2.941) | 0.033 | 2.062 (0.959–4.431) | 0.064 | |
| Visceral adipose tissue area index, cm2/m2 (≥30.39 for male, 44.70 for female) | 1.600 (0.985–2.600) | 0.058 | 1.770 (1.036–3.021) | 0.037 | |
HCC, hepatocellular carcinoma; CI, confidence interval; BMI, body mass index; HBV, hepatitis B virus; HCV, hepatitis C virus; MELD, model for end-stage liver disease; AFP, alpha-fetoprotein; TNM, tumor-node-metastasis; HU, Hounsfield unit.