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. 2020 Apr;9(4):2780–2800. doi: 10.21037/tcr.2020.02.44

Table 1. Details of enrolled studies for current meta-analysis and systematic review.

Gene-polymorphism First author Year Ethnicity Source of control Case Control
WW MW MM WW MW MM Y (HWE)
XRCC1-rs1799782 David-Beabes et al. 2001 African P-B 142 10 2 205 36 2 Y
David-Beabes et al. 2001 Caucasian P-B 158 22 0 407 54 0 Y
Chen et al. 2002 Asian P-B 48 44 11 57 40 5 Y
Ratnasinghe et al. 2003 Asian P-B 52 47 9 85 104 21 Y
Shen et al. 2005 Asian P-B 65 41 12 64 40 8 Y
Chan et al. 2005 Asian H-B 50 22 3 79 67 16 Y
Schneider et al. 2005 Caucasian H-B 389 53 4 544 75 3 Y
Hung et al. 2005 Caucasian H-B 1878 259 10 1828 292 12 Y
Hu et al. 2005 Asian H-B 335 311 64 339 308 63 Y
Zienolddiny et al. 2006 Caucasian P-B 309 26 1 368 35 2 Y
Landi et al. 2006 Caucasian H-B 263 32 1 262 53 1 Y
Matullo et al. 2006 Caucasian Mixed 98 16 2 951 141 2 Y
Hao et al. 2006 Asian P-B 524 409 91 572 459 87 Y
De Ruyck et al. 2007 Caucasian H-B 101 8 1 93 17 0 Y
Pachouri et al. 2007 Caucasian P-B 40 39 24 52 47 23 N
Improta et al. 2008 Caucasian P-B 78 9 7 104 17 0 Y
Yin et al. 2008 Asian H-B 120 98 23 119 109 21 Y
Li et al. 2008 Asian H-B 184 136 30 196 133 21 Y
Chang et al. 2009 African P-B 221 34 0 248 31 1 Y
Yin et al. 2009 Asian H-B 29 21 1 28 38 8 Y
Chang et al. 2009 Caucasian P-B 89 23 1 223 66 10 Y
Tanaka et al. 2010 Asian H-B 28 15 7 25 23 2 Y
Buch et al. 2011 Caucasian H-B 682 36 2 839 83 6 N
Mei et al. 2013 Asian P-B 138 90 23 155 119 27 Y
Du et al. 2014 Asian P-B 68 33 19 88 21 11 N
Yoo et al. 2014 Asian P-B 281 249 67 268 255 54 Y
Cătană et al. 2015 Caucasian P-B 89 3 10 197 22 3 N
Han et al. 2015 Asian P-B 99 90 21 106 87 17 Y
Zhu et al. 2015 Asian P-B 180 137 3 111 206 29 N
Singh et al. 2016 Caucasian P-B 256 72 2 267 55 3 Y
XRCC1-rs25487 Divine et al. 2001 Caucasian H-B 82 61 29 65 64 14 Y
David-Beabes et al. 2001 African P-B 105 46 3 164 70 9 Y
Ratnasinghe et al. 2001 Asian P-B 59 40 8 117 80 11 Y
David-Beabes et al. 2001 Caucasian P-B 87 76 17 186 217 58 Y
Chen et al. 2002 Asian P-B 55 43 5 52 40 7 Y
Park et al. 2002 Asian P-B 100 75 17 81 48 6 Y
Misra et al. 2003 Caucasian P-B 151 140 24 154 130 29 Y
Zhou et al. 2003 Caucasian P-B 467 468 156 551 545 143 Y
Harms et al. 2004 Caucasian H-B 59 42 9 56 55 8 Y
Vogel et al. 2004 Caucasian H-B 117 104 35 108 121 40 Y
Ito et al. 2004 Asian H-B 98 66 14 253 169 26 Y
Popanda et al. 2004 Caucasian H-B 186 214 63 171 222 67 Y
Liu et al. 2004 Caucasian H-B 400 397 138 551 539 143 Y
Li et al. 2005 Asian H-B 22 20 8 27 21 2 Y
Shen et al. 2005 Asian P-B 72 40 4 54 51 4 Y
Chan et al. 2005 Asian H-B 40 31 4 90 61 11 Y
Schneider et al. 2005 Caucasian H-B 199 198 49 264 280 78 Y
Hu et al. 2005 Asian H-B 378 284 48 370 282 58 Y
Zhang et al. 2005 Asian H-B 535 363 102 531 380 89 Y
Hung et al. 2005 Caucasian H-B 844 951 254 874 881 260 Y
Zienolddiny et al. 2006 Caucasian P-B 129 171 31 151 186 54 Y
Hao et al. 2006 Asian H-B 566 376 82 585 432 101 Y
Matullo et al. 2006 Caucasian Mixed 51 58 7 484 482 128 Y
De Ruyck et al. 2007 Caucasian H-B 38 53 18 46 50 13 Y
Yin et al. 2007 Asian H-B 138 65 2 132 52 9 Y
Pachouri et al. 2007 Caucasian P-B 53 38 12 35 70 17 Y
López-Cima et al. 2007 Caucasian H-B 222 219 75 217 234 82 Y
Improta et al. 2008 Caucasian P-B 42 41 11 53 61 7 N
Sreeja et al. 2008 Caucasian P-B 78 86 47 102 80 29 N
Li et al. 2008 Asian H-B 168 139 43 201 123 26 Y
Yin et al. 2009 Asian H-B 31 13 1 36 15 1 Y
Cote et al. 2009 African P-B 86 23 6 88 28 5 Y
Chang et al. 2009 African P-B 182 69 4 209 65 5 Y
Chang et al. 2009 Caucasian P-B 54 47 12 155 127 16 Y
Cote et al. 2009 Caucasian P-B 172 159 56 160 200 46 Y
Li et al. 2011 Asian H-B 236 193 26 220 196 27 Y
Kiyohara et al. 2012 Asian H-B 243 171 48 242 121 16 Y
Natukula et al. 2013 Caucasian P-B 40 19 41 55 10 36 N
Ouyang et al. 2013 Asian P-B 52 22 8 105 86 10 Y
Mei et al. 2013 Asian P-B 142 95 14 145 126 30 Y
Letkova et al. 2013 Caucasian P-B 138 202 42 157 185 37 Y
Du et al. 2014 Asian P-B 81 16 23 95 15 10 N
Sarlinova et al. 2014 Caucasian P-B 17 24 9 23 41 5 N
Uppal et al. 2014 Caucasian P-B 18 32 50 12 65 23 N
Saikia et al. 2014 Caucasian P-B 146 103 23 322 188 34 Y
Yoo et al. 2014 Asian P-B 344 207 47 313 245 33 Y
Han et al. 2015 Asian P-B 156 34 20 164 30 16 N
Wang et al. 2015 Asian P-B 259 24 217 273 43 184 N
Zhu et al. 2015 Asian P-B 221 80 19 269 72 5 Y
Cătană et al. 2015 Caucasian P-B 43 43 16 112 86 24 Y
Liu et al. 2016 Asian P-B 162 114 32 162 81 10 Y
Singh et al. 2016 Caucasian P-B 93 186 51 79 176 70 Y
XRCC1-rs25489 Ratnasinghe et al. 2001 Asian P-B 83 20 3 177 32 0 Y
Misra et al. 2003 Caucasian P-B 260 47 2 260 42 0 Y
Vogel et al. 2004 Caucasian H-B 229 26 1 241 28 0 Y
Shen et al. 2005 Asian P-B 76 30 5 81 28 1 Y
Schneider et al. 2005 Caucasian H-B 404 40 2 562 60 0 Y
Hung et al. 2005 Caucasian H-B 1901 181 6 1896 190 6 Y
Zienolddiny et al. 2006 Caucasian P-B 296 31 2 350 24 3 N
Hao et al. 2006 Asian H-B 848 169 7 904 204 10 Y
De Ruyck et al. 2007 Caucasian H-B 105 4 0 96 14 0 Y
Yin et al. 2008 Asian H-B 190 46 2 179 59 4 Y
Li et al. 2008 Asian H-B 266 79 5 74 72 4 N
Yin et al. 2009 Asian H-B 41 7 1 52 18 2 Y
Chang et al. 2009 Caucasian P-B 86 25 1 242 51 5 Y
Yoo et al. 2014 Asian P-B 506 88 5 448 127 5 Y
Han et al. 2015 Asian P-B 100 87 23 109 82 19 Y
Singh et al. 2016 Caucasian P-B 32 250 48 26 268 31 N
XRCC1-rs3213245 Hu et al. 2005 Asian H-B 500 198 12 558 148 4 Y
Hao et al. 2006 Asian H-B 783 223 18 924 182 12 Y
De Ruyck et al. 2007 Caucasian H-B 37 53 19 40 52 18 Y
Li et al. 2008 Asian H-B 264 75 11 291 55 4 Y
Hsieh et al. 2009 Asian P-B 251 40 3 250 37 1 Y
Tang et al. 2014 Asian P-B 212 163 45 225 181 19 N
Yoo et al. 2015 Asian P-B 494 104 4 462 111 4 Y
XRCC1-rs3547 Yin et al. 2008 Asian H-B 183 43 1 191 49 2 Y
Yin et al. 2009 Asian H-B 35 12 0 61 9 1 Y
Chang et al. 2009 Caucasian P-B 62 45 6 177 99 23 Y
Chang et al. 2009 African P-B 114 104 37 126 122 32 Y
Singh et al. 2016 Caucasian P-B 61 142 127 124 127 74 N
XRCC1-rs915927 Matullo et al. 2006 Caucasian Mixed 36 58 22 342 508 243 N
Yin et al. 2008 Asian H-B 169 68 2 203 43 0 Y
Yin et al. 2009 Asian H-B 36 14 1 66 7 0 Y
Singh et al. 2016 Caucasian P-B 134 164 32 147 139 39 Y
APEX1-rs1130409 Misra et al. 2003 Caucasian P-B 64 167 79 65 160 77 Y
Ito et al. 2004 Asian H-B 62 84 32 159 226 64 Y
Popanda et al. 2004 Caucasian H-B 135 235 89 118 233 106 Y
Shen et al. 2005 Asian P-B 30 61 26 37 61 15 Y
Zienolddiny et al. 2006 Caucasian P-B 117 67 80 138 60 122 N
Matullo et al. 2006 Caucasian P-B 33 56 27 309 526 259 Y
De Ruyck et al. 2007 Caucasian H-B 21 60 29 41 41 28 N
Agachan et al. 2009 Caucasian P-B 38 40 20 45 17 5 Y
Lu et al. 2009 Asian H-B 182 228 90 176 265 76 Y
Lo et al. 2009 Asian H-B 261 349 119 272 332 118 Y
Deng et al. 2010 Asian P-B 123 143 49 97 159 58 Y
Li et al. 2011 Asian H-B 179 199 77 172 213 58 Y
Xue et al. 2013 Asian H-B 116 183 111 130 190 90 Y
Pan et al. 2013 Asian H-B 48 273 498 25 247 531 Y
Li et al. 2014 Asian H-B 2 11 3 50 46 14 Y
Sevilya et al. 2015 Caucasian H-B 34 50 15 42 46 11 Y
APEX1-rs1760944 Lu et al. 2009 Asian H-B 184 241 75 170 238 109 Y
Lo et al. 2009 Asian H-B 271 332 122 234 341 153 Y
Li et al. 2011 Asian H-B 162 227 66 143 206 94 Y
Pan et al. 2013 Asian H-B 114 384 321 98 369 336 Y
Li et al. 2014 Asian H-B 3 10 3 36 56 18 Y
APEX1-rs2307486 Zienolddiny et al. 2006 Caucasian P-B 263 76 1 276 124 10 Y
Lo et al. 2009 Asian H-B 669 59 0 659 64 2 Y
Li et al. 2014 Asian H-B 11 2 0 103 7 0 Y
OGG1-rs1052133 Kohno et al. 1998 Asian Mixed 16 19 10 15 20 7 Y
Sugimura et al. 1999 Mixed H-B 85 115 41 63 107 27 Y
Wikman et al. 2000 Caucasian P-B 68 32 5 60 43 2 Y
Marchand et al. 2002 Mixed P-B 15 31 29 29 48 19 Y
Marchand et al. 2002 Caucasian P-B 78 39 9 98 53 8 Y
Sunaga et al. 2002 Asian H-B 54 106 38 50 66 36 Y
Marchand et al. 2002 Asian P-B 30 40 27 50 74 26 Y
Ito et al. 2002 Asian H-B 40 71 27 68 118 54 Y
Lan et al. 2004 Asian P-B 37 61 20 51 43 15 Y
Park et al. 2004 Caucasian P-B 88 60 12 255 87 8 Y
Vogel et al. 2004 Caucasian P-B 149 93 14 159 91 19 Y
Liang et al. 2005 Asian H-B 27 132 68 28 123 76 N
Hung et al. 2005 Caucasian H-B 1401 661 93 1368 716 79 Y
Loft et al. 2006 Caucasian P-B 144 93 14 154 88 19 Y
Zienolddiny et al. 2006 Caucasian P-B 182 100 44 194 117 75 N
Kohno et al. 2006 Asian H-B 285 544 268 123 190 81 Y
Sorensen et al. 2006 Caucasian P-B 254 155 22 479 284 33 Y
Matullo et al. 2006 Caucasian P-B 66 46 4 673 371 50 Y
De Ruyck et al. 2007 Caucasian H-B 74 33 3 60 46 4 Y
Hatt et al. 2008 Caucasian P-B 92 58 8 93 59 12 Y
Karahalil et al. 2008 Caucasian H-B 86 65 14 115 106 29 Y
Miyaishi et al. 2009 Asian H-B 27 55 26 39 54 28 Y
Chang et al. 2009 African P-B 170 78 6 202 70 8 Y
Chang et al. 2009 Caucasian P-B 53 47 12 135 132 29 Y
Chang et al. 2009 Asian P-B 142 518 436 154 482 361 Y
Okasaka et al. 2009 Asian H-B 117 257 141 250 544 236 Y
Liu et al. 2010 Asian H-B 68 158 132 110 294 312 N
Janik et al. 2011 Caucasian H-B 48 24 16 57 21 1 Y
Li et al. 2011 Asian H-B 83 208 164 60 219 164 Y
Qian et al. 2011 Asian H-B 100 288 193 125 291 185 Y
Cheng et al. 2012 Asian P-B 26 9 15 17 3 10 N
Ouyan et al. 2013 Asian P-B 14 42 26 40 94 67 Y
Letkova et al. 2013 Caucasian P-B 244 119 19 250 110 18 Y
Xue et al. 2013 Asian H-B 55 178 177 68 200 142 Y
Doherty et al. 2013 Caucasian P-B 440 265 39 873 519 85 Y
Wang et al. 2015 Asian P-B 77 182 241 80 165 25 N
Qin et al. 2016 Asian P-B 59 121 37 72 124 30 N
LIG1-rs20579 Landi et al. 2006 Caucasian Mixed 206 73 6 245 61 0 Y
Chang et al. 2008 Caucasian P-B 72 36 5 217 75 7 Y
Chang et al. 2008 African P-B 150 92 13 137 117 26 Y
Lee et al. 2008 Caucasian P-B 294 118 11 586 187 7 Y
Sakoda et al. 2012 Caucasian P-B 583 141 18 1126 312 36 N
LIG1-rs3730931 Landi et al. 2006 Caucasian Mixed 220 64 5 255 52 2 Y
Chang et al. 2008 Caucasian P-B 79 30 4 226 67 6 Y
Chang et al. 2008 African P-B 151 92 11 158 103 19 Y
Sakoda et al. 2012 Caucasian P-B 595 137 11 1137 313 26 Y
LIG1-rs156641 Chang et al. 2008 African P-B 189 62 4 215 60 5 Y
Chang et al. 2008 Caucasian P-B 59 43 11 143 126 30 Y
Sakoda et al. 2012 Caucasian P-B 271 352 121 596 709 164 N
LIG1-rs20581 Chang et al. 2008 African P-B 176 73 6 199 68 13 N
Chang et al. 2008 Caucasian P-B 38 48 27 89 151 59 Y
Lee et al. 2008 Caucasian P-B 78 148 86 142 346 155 Y
LIG1-rs439132 Chang et al. 2008 Caucasian P-B 108 5 0 269 29 1 Y
Lee et al. 2008 Caucasian P-B 326 39 6 585 54 2 Y
Chang et al. 2008 African P-B 129 112 14 117 91 12 Y
MUTYH-rs3219489 Al-tassan et al. 2003 Caucasian P-B 142 109 14 58 36 7 Y
Miyaishi et al. 2009 Asian P-B 22 57 29 37 69 15 N
Qian et al. 2011 Asian P-B 230 261 90 243 283 77 Y
Doherty et al. 2013 Caucasian P-B 417 279 42 825 562 79 Y
PARP1-rs1136410 Zhang et al. 2005 Asian H-B 307 509 184 359 504 137 Y
Yin et al. 2011 Mixed H-B 117 35 7 50 12 2 Y
Xue et al. 2013 Asian H-B 129 202 79 138 205 67 Y
Yu et al. 2014 Asian H-B 46 164 163 34 164 162 Y
Wang et al. 2015 Asian P-B 151 97 252 14 109 251 Y

M, mutant allele; W, wild type allele; P-B, population-based; H-B, hospital-based; Mixed, more than one ethnicity; N.A., not mentioned; Y, studies that conforms to HWE; N, study that deviates from HWE.