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. 2021 Mar;10(3):1368–1377. doi: 10.21037/tcr-20-2627

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2021 Translational Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

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Huaier promoted the suppressing effects of gemcitabine on the migration and invasion of PaTu8988 cells. A and B: The results of wound migration assays in PaTu8988 cells left untreated ortreated with gemcitabine (8 µM), Huaier (6 mg/mL), or their combination. (A) Representative images of would migration assays (magnification, ×200). (B) Quantitative analysis of the migration ability of PaTu8988 cells. (C,D) The results of Transwell invasion assays in PaTu8988 cells left untreated or treated with gemcitabine (8 µM), Huaier (6 mg/mL), or the combination. (C) Representative Transwell invasion images (crystal violet staining, ×200). (D) Quantitative analysis of the effect of drugs on cell invasion. *, P<0.05 (n=6 per group) compared with the untreated group or single drug groups.