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. 2020 Nov;9(11):6988–7000. doi: 10.21037/tcr-19-2133

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2020 Translational Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

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MiR-185-3p inhibited the activity of PI3K/Akt signaling pathway by inhibiting cathepsin D. (A) qRT-PCR analysis of cathepsin D level after transfection with p-cathepsin D or p-NC. (B) Western blotting analysis of PI3K/Akt related proteins. Transfection with p-cathepsin D could increase the level of p-PI3K and p-Akt (Ser 473), which was compromised by either transfection with miR-185-3p mimics or the administration of LY294002. The quantification of investigated proteins was normalized against GAPDH. *, P<0.05; **, P<0.01.