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. 2020 Nov;9(11):6988–7000. doi: 10.21037/tcr-19-2133

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2020 Translational Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

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MiR-185-3p regulated EMT via cathepsin D mediated PI3K/Akt signaling pathway. (A) qRT-PCR analysis of EMT markers in AGS and SGC7901 cells after transfection with miR-185-3p mimics, p-cathepsin D, miR-185-3p mimics and p-cathepsin D, as well as p-cathepsin D followed by administration of LY294002. (B) Western blotting of EMT markers in AGS and SGC7901 cells after transfection. The quantification of EMT markers was normalized against GAPDH. (C) Cell scratch assay of AGS cells after transfection. Left, images of the migration of cells after incubation for 24 h; right, quantification of the cell migration. (D) Transwell assay of AGS cells after transfection. Left, images of migration cells in the lower chamber; right, cell counts of the migration cells in the lower chamber. *, P<0.05; **, P<0.01.