Table 4. Univariate and multivariate Cox’s proportional hazard model regression analyses of factors affecting DFS.

Items	Univariate Cox’s regression			Multivariate Cox’s regression
	P value	HR (95% CI)		P value	HR (95% CI)
ITGA7 expression (high vs. low)	<0.001	1.772 (1.346–2.333)		0.027	1.415 (1.041–1.923)
CD44 expression (high vs. low)	0.022	1.692 (1.078–2.656)		0.054	1.576 (0.992–2.503)
CD133 expression (high vs. low)	0.005	1.676 (1.170–2.401)		0.153	1.314 (0.903–1.912)
Age (>60 vs. ≤60 years)	0.292	1.150 (0.887–1.490)		0.124	1.235 (0.944–1.615)
Gender (male vs. female)	0.718	0.942 (0.682–1.301)		0.884	1.025 (0.732–1.437)
Higher pathological grade	<0.001	1.466 (1.197–1.795)		0.004	1.389 (1.108–1.741)
Tumor size (>5 vs. ≤5 cm)	0.322	1.144 (0.876–1.493)		0.427	0.877 (0.634–1.213)
LYN (yes vs. no)	<0.001	1.749 (1.338–2.286)		0.003	1.783 (1.217–2.612)
Higher TNM stage	0.002	1.285 (1.098–1.505)		0.692	0.949 (0.733–1.229)

P value <0.05 was considered significant. DFS, disease-free survival; HR, hazard ratio; ITGA7, integrin-α7; LYN, lymph node metastasis.