Table 5. Univariate and multivariate Cox’s proportional hazard model regression analyses of factors affecting OS.

Items	Univariate Cox’s regression			Multivariate Cox’s regression
	P value	HR (95% CI)		P value	HR (95% CI)
ITGA7 expression (high vs. low)	<0.001	2.005 (1.456–2.760)		0.006	1.628 (1.147–2.311)
CD44 expression (high vs. low)	0.045	1.717 (1.012–2.912)		0.150	1.493 (0.866–2.574)
CD133 expression (high vs. low)	0.010	1.656 (1.131–2.426)		0.222	1.281 (0.861–1.908)
Age (>60 vs. ≤60 years)	0.755	1.047 (0.785–1.396)		0.443	1.125 (0.833–1.519)
Gender (male vs. female)	0.725	0.938 (0.657–1.340)		0.941	1.014 (0.701–1.467)
Higher pathological grade	<0.001	1.522 (1.216–1.906)		0.006	1.428 (1.106–1.844)
Tumor size (>5 vs. ≤5 cm)	0.058	1.342 (0.990–1.818)		0.752	1.059 (0.741–1.515)
LYN (yes vs. no)	<0.001	2.268 (1.693–3.039)		<0.001	2.652 (1.737–4.049)
Higher TNM stage	0.001	1.366 (1.142–1.634)		0.150	0.809 (0.607–1.080)

P value <0.05 was considered significant. OS, overall survival; HR, hazard ratio; ITGA7, integrin-α7; LYN, lymph node metastasis.