| Dose-per-fraction |
1.8–2 Gy/fraction |
Several protocols are used worldwide; approximately 7.5–22.5 Gy/fraction (7-11) |
| Total fractions (treatment duration) |
28–33 fractions in 6–7 weeks |
Several protocols are used worldwide; approximately, within 1–2 weeks (7-11) |
| Total dose |
60–66 Gy |
Several protocols are used worldwide; in Japan, 48 Gy in 4 fractions is most frequently used; followed by 50 Gy in 5 fractions, and 60 Gy in 8 fractions (7); usually, for central lesions, total dose and dose-per-fraction are modified for example 50 Gy in 5 fractions and 56 Gy in 7 fractions, however, several prospective trials are undergoing regarding the treatment of central lesions |
| Biological effective dose α/β=10 (BED10) |
72 Gy for 60 Gy/30 fractions |
105.6 Gy for 48 Gy/4 fractions, 100 Gy for 50 Gy/5 fractions; BED10>100 Gy is related with good prognosis (12,13) |
| Dose contribution |
Band or box-shaped irradiation area including target lesion; hence, normal organs around the target are widely included |
Almost target fitted irradiation area with minimal margin for the target; hence, decrease dose of normal organ near the target is possible |
