Table 7. Multivariate analysis of the relationships between CEUS indicators, tumor diameter, MVI, differentiation degree, and HCC recurrence.
| Variables | Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|
| OR | 95% CI | P | OR | 95% CI | P | ||
| Differentiation degree | |||||||
| Highly-differentiated | 1.000 | – | – | 1.000 | – | – | |
| Moderately-differentiated | 1.527 | 0.300–7.787 | 0.610 | 0.231 | 0.029–1.841 | 0.167 | |
| Poorly-differentiated | 10.5 | 2.181–50.544 | 0.003* | 0.202 | 0.017–2.446 | 0.209 | |
| Tumor diameter | |||||||
| <2 | 1.000 | – | – | 1.000 | – | – | |
| ≥2 | 5.691 | 2.141–15.131 | <0.001* | 0.469 | 0.124–1.777 | 0.265 | |
| MVI | |||||||
| Negative | 1.000 | – | – | 1.000 | – | – | |
| Positive | 2.852 | 1.229–6.618 | 0.015* | 5.569 | 1.256–24.696 | 0.024* | |
| RT | 0.581 | 0.462–0.730 | <0.001* | 0.619 | 1.256–24.696 | 0.005* | |
| TTP | 0.722 | 0.589–0.884 | 0.722 | 0.786 | 0.445–0.862 | 0.034* | |
| Enhancement rate | 33.157 | 2.137–514.508 | 0.012* | 3.806 | 0.630–0.981 | 0.494 | |
| Imax | 0.986 | 0.974–0.997 | 0.013* | 0.980 | 0.083–175.298 | 0.023* | |
*, P<0.05. CEUS, contrast-enhanced ultrasound; HCC, hepatocellular carcinoma; MVI, microvascular invasion; RT, rise time; TTP, time to peak; Imax, intensity maximum.