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. 2020 Sep;9(9):5528–5543. doi: 10.21037/tcr-20-686

Table 1. Potential target transcription factors of the upregulated hub genes.

Transcription factors Numbers Hub genes
MYC 9 BIRC5, CDC6, CDC25A, CDK1, CCNF, CCNE2, CCNE1, CHEK1, CDC25B
E2F1 8 CDC6, CDC25A, CDK1, CCNE2, CCNE1, CHEK1, CDC25B, CCNF
KDM5B 8 BIRC5, CDC6, CDC25A, CDK1, CCNF, CCNE2, CCNE1, CHEK1
MYCN 7 BIRC5, CDC6, CDC25A, CCNF, CCNE2, CCNE1, CHEK1
SOX2 7 BIRC5, CDC25A, CDK1, CCNE2, CCNE1, CDC25B, CHEK1
KLF4 7 BIRC5, CDK1, CCNF, CCNE2, CCNE1, CHEK1, CDC25B
CREM 7 BIRC5, CDC6, CDC25A, CCNF, CCNE2, CCNE1, CHEK1
CREB1 7 BIRC5, CDC6, CDC25A, CCNF, CCNE1, CHEK1, CDC25B
FOXC1 6 CDK1, CDC25A, CCNE2, CHEK1, CDC6, CCNE1
SAP30 6 BIRC5, CCNE1, CCNE2, CDC25A, CDC6, CHEK1
PHF8 6 CDC25A, CCNE2, BIRC5CCNE1, CDC6, CHEK1
CEBPB 6 CDC6, CDC25A, CCNF, CDC25B, CHEK1, CCNE2
PPARG 6 CDC6, CDK1, BIRC5, CCNE2CDC25B, CHEK1