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. 2020 Sep;9(9):5528–5543. doi: 10.21037/tcr-20-686

Table 2. Potential target transcription factors of the downregulated hub genes.

Transcription factors Numbers Hub genes
HNF4A 5 ESR1, FOXO1, IGF1, SERPINE1, CAT
PPARG 5 ESR1, FOXO1, IGF1, SERPINE1, CAT
NFE2L2 4 ESR1, IGF1, SERPINE1, CAT
SMAD4 4 ESR1, FOXO1, IGF1, SERPINE1
EGR1 4 ESR1, FOXO1, SERPINE1, CAT
STAT3 4 ESR1, FOXO1, IGF1, SERPINE1
TP63 4 FOXO1, IGF1, SERPINE1, CAT
E2F1 4 FOXO1, IGF1, SERPINE1, CAT
TCF4 3 ESR1, IGF1, CAT
RUNX1 3 ESR1, SERPINE1, CAT
FOXA2 3 ESR1, IGF1, SERPINE1
BACH1 3 ESR1, FOXO1, IGF1
CREB1 3 ESR1, FOXO1, IGF1
FLI1 3 FOXO1, IGF1, SERPINE1
SPI1 3 FOXO1, SERPINE1, CAT
SOX2 3 FOXO1, IGF1, SERPINE1
TFAP2A 3 ESR1, FOXO1, IGF1
GATA2 3 ESR1, SERPINE1, CAT
RAD21 3 FOXO1, IGF1, CAT
ZNF354C 3 ESR1, IGF1, SERPINE1
FOXC1 3 ESR1, IGF1, CAT