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. 2021 Jul;10(7):3548–3559. doi: 10.21037/tcr-21-559

Figure 5.

Figure 5

Konckdown of SIRT1 can Suppressed the proliferation, migration and invasion of human CRC cell lines. (A) Relative expression of SIRT1 in SW480 cells stable knockdown SIRT1 was detected by qRT-PCR (***P<0.001; NS, P>0.05). (B) Relative expression of SIRT1 in SW620 cells stable knockdown SIRT1 was detected by qRT-PCR (***P<0.001; NS, P>0.05). (C) The proliferation of SW480 cell with stable knockdown SIRT1 was detected by CCK8 assay. (D) The proliferation of SW620 cell with stable knockdown SIRT1 was detected by CCK8 assay. (E,F) The migration of SW480 and SW620 cell with stable knockdown SIRT1 was detected by transwell (Scale bars =50 µm. Bars, s.e.m.; ***P<0.001). (G,H) The invasion of SW480 and SW620 cell with stable knockdown SIRT1 was detected by transwell (Scale bars =50 µm. Bars, s.e.m.; ***P<0.001), Each experiment was repeated three times, then the deviations were eliminated and the average value was taken.